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Table 3 Parasite reduction ratio at 12 and 24 hours compared with quinine: mixed model results

From: Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies

 

12 hr final model

24 hr descriptive model**

24 hr final model

 

%

p-value

N

%

p-value

N

Odds Ratio

p-value

Single dose Rectal Artemisinin vs Parenteral Quinine

Parenteral quinine

48.6

 

35

68.7

 

30

  

Rectal artemisinin

72.3

0.337

46

95.5

0.29

46

8.2*

0.000

Multiple dose Rectal Artesunate vs Parenteral Quinine

Parenteral Quinine

27.5

 

123

67.1

 

106

  

Multiple rectal artesunate

56.5

0.04

272

89

0.004

254

11.03

0.009

Multiple Rectal Artemisinin vs Parenteral Quinine

Parenteral Quinine

48.6

 

35

68.7

 

30

  

Multiple rectal artemisinin

63.3

0.343

98

89.1

0.090

80

3.70*

0.004

Single dose Rectal Artesunate vs Parenteral Quinine

Parenteral

36

 

293

63.7

 

106

  

Rectal

79

0.000

123

99

0.000

264

23.5

0.000

Age 5–14 yrs***

-12

0.043

 

-9.4

0.015

 

0.33

0.015

Age >14 yrs***

-18

0.026

 

-6.9

0.152

 

0.32

0.021

Severe disease

   

11.5

0.045

   
  1. * No solution was found for the mixed model. Corresponding non-hierarchical regression used instead.
  2. ** Descriptive estimates of parasite reductions at 24 hours are provided only for comparisons with 12 hour estimates, see section 'Statistical analysis'
  3. *** Reference category is <5 years