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Table 3 Parasite reduction ratio at 12 and 24 hours compared with quinine: mixed model results

From: Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies

  12 hr final model 24 hr descriptive model** 24 hr final model
  % p-value N % p-value N Odds Ratio p-value
Single dose Rectal Artemisinin vs Parenteral Quinine
Parenteral quinine 48.6   35 68.7   30   
Rectal artemisinin 72.3 0.337 46 95.5 0.29 46 8.2* 0.000
Multiple dose Rectal Artesunate vs Parenteral Quinine
Parenteral Quinine 27.5   123 67.1   106   
Multiple rectal artesunate 56.5 0.04 272 89 0.004 254 11.03 0.009
Multiple Rectal Artemisinin vs Parenteral Quinine
Parenteral Quinine 48.6   35 68.7   30   
Multiple rectal artemisinin 63.3 0.343 98 89.1 0.090 80 3.70* 0.004
Single dose Rectal Artesunate vs Parenteral Quinine
Parenteral 36   293 63.7   106   
Rectal 79 0.000 123 99 0.000 264 23.5 0.000
Age 5–14 yrs*** -12 0.043   -9.4 0.015   0.33 0.015
Age >14 yrs*** -18 0.026   -6.9 0.152   0.32 0.021
Severe disease     11.5 0.045    
  1. * No solution was found for the mixed model. Corresponding non-hierarchical regression used instead.
  2. ** Descriptive estimates of parasite reductions at 24 hours are provided only for comparisons with 12 hour estimates, see section 'Statistical analysis'
  3. *** Reference category is <5 years