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Table 1 Studies for which individual patient data was provided, by study, treatment and number of patients

From: Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies

Region Country Study Identification* [Ref] Treatment Group Number of Patients Studied Total Number of Patients
     Moderately Severe Severe Uncomplicated  
Africa Ghana Krishna 1996 [10] Artesunate ir, single dose 23    23
    Artemisinins** parenteral 11    11
  Kenya Bhatt 1994–5 [36] Artesunate ir, multiple dose   23   23
  Malawi Molyneux 1997–8 [30] Artesunate ir, single dose 86    86
    Quinine parenteral 22    22
  South Africa Barnes 1998 [30] Artesunate ir, single dose 27    27
    Quinine parenteral 8 6   14
    Quinine parenteral+ Artesunate ir   5   5
  Uganda Aceng 2002–3 [32] Artemether ir, single dose   51   51
    Quinine parenteral   52   52
Total Number of Patients – Africa 177 137   314
Asia- Oceania Myanmar Than 1998 Artesunate ir, multiple dose   100   100
  Papua New Guinea Karunajeewa 2001 [37] Artesunate ir, multiple dose    48 48
  Papua New Guinea Karunajeewa 2003–4 [34] Artesunate ir, multiple dose   41   41
    Artemisinins parenteral   38   38
  Thailand Looareesuwan 1996 Artesunate ir, single dose 26    26
    Artemisinins parenteral 24    24
  Thailand Van Vugt 1997–9 Artesunate ir, single dose 44    44
    Artesunate po 17    17
  Thailand Looareesuwan 1995 [35] Artesunate ir, multiple dose 60    60
  Thailand Looareesuwan 2000 Artesunate ir, single dose 69    69
  Vietnam Phuong 1992–5 [31] Artemisinin, multiple dose   46   46
    Artemisinins parenteral   40   40
    Quinine parenteral   35   35
  Vietnam Vinh 1992–4 [33] Artemisinin ir, multiple dose   52   52
    Artemisinins parenteral   123   123
  Vietnam Hien 1998 Artemisinin ir, single dose   46   46
    Artesunate ir, single dose   44   44
Total Number of Patients – Asia 240 565 48 853
Grand Total 417 702 48 1167
  1. * Study Identification: Investigator name and year of patient enrolment [References are included where available].
  2. ** Artemisinins parenteral: this consisted of Artemether or Artesunate administered via intra-muscular or intravenous route
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BMC Infectious Diseases

ISSN: 1471-2334

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