Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies

BMC Infectious Diseases

Table 1 Studies for which individual patient data was provided, by study, treatment and number of patients

Region	Country	Study Identification* [Ref]	Treatment Group	Number of Patients Studied			Total Number of Patients
				Moderately Severe	Severe	Uncomplicated
Africa	Ghana	Krishna 1996 [10]	Artesunate ir, single dose	23			23
			Artemisinins** parenteral	11			11
	Kenya	Bhatt 1994–5 [36]	Artesunate ir, multiple dose		23		23
	Malawi	Molyneux 1997–8 [30]	Artesunate ir, single dose	86			86
			Quinine parenteral	22			22
	South Africa	Barnes 1998 [30]	Artesunate ir, single dose	27			27
			Quinine parenteral	8	6		14
			Quinine parenteral+ Artesunate ir		5		5
	Uganda	Aceng 2002–3 [32]	Artemether ir, single dose		51		51
			Quinine parenteral		52		52
Total Number of Patients – Africa				177	137		314
Asia- Oceania	Myanmar	Than 1998	Artesunate ir, multiple dose		100		100
	Papua New Guinea	Karunajeewa 2001 [37]	Artesunate ir, multiple dose			48	48
	Papua New Guinea	Karunajeewa 2003–4 [34]	Artesunate ir, multiple dose		41		41
			Artemisinins parenteral		38		38
	Thailand	Looareesuwan 1996	Artesunate ir, single dose	26			26
			Artemisinins parenteral	24			24
	Thailand	Van Vugt 1997–9	Artesunate ir, single dose	44			44
			Artesunate po	17			17
	Thailand	Looareesuwan 1995 [35]	Artesunate ir, multiple dose	60			60
	Thailand	Looareesuwan 2000	Artesunate ir, single dose	69			69
	Vietnam	Phuong 1992–5 [31]	Artemisinin, multiple dose		46		46
			Artemisinins parenteral		40		40
			Quinine parenteral		35		35
	Vietnam	Vinh 1992–4 [33]	Artemisinin ir, multiple dose		52		52
			Artemisinins parenteral		123		123
	Vietnam	Hien 1998	Artemisinin ir, single dose		46		46
			Artesunate ir, single dose		44		44
Total Number of Patients – Asia				240	565	48	853
Grand Total				417	702	48	1167

* Study Identification: Investigator name and year of patient enrolment [References are included where available].
** Artemisinins parenteral: this consisted of Artemether or Artesunate administered via intra-muscular or intravenous route

ISSN: 1471-2334