Table 7 TNF-α gene polymorphism and femoral head necrosis in cured SARS patients.
SNP site | Femoral head necrosis (%) | Non-femoral head necrosis (%) | OR* (95%C.I.) | P |
|---|---|---|---|---|
-1031 | ||||
Genotype | ||||
TT | 6(40) | 28(80) | ||
CT | 8(53.7) | 7(20) | 5.33(1.39–20.45) | 0.01 |
CC | 1(6.7) | 0 | 5.67(2.74–11.71)$ | 0.04 |
Allele | ||||
T | 66.67 | 90.00 | ||
C | 33.33 | 10.00 | ||
-863 | ||||
Genotype | ||||
CC | 9(56.3) | 33(89.2) | ||
AC | 7(43.7) | 4(10.8) | 6.42(1.53–26.88) | 0.01 |
Allele | ||||
C | 78.12 | 94.59 | ||
A | 21.88 | 5.41 | ||
-857 | ||||
Genotype | ||||
CC | 12(75) | 26(70.3) | ||
CT | 4(25) | 11(29.7) | 0.78(0.21–2.99) | 0.73 |
Allele | ||||
C | 87.50 | 85.14 | ||
T | 12.50 | 14.86 | ||
-572 | ||||
Genotype | ||||
AA | 16(100) | 36(97.3) | ||
AC | 0 | 1(2.7) | 1.44(1.21–1.73)‡ | 0.70 |
Allele | ||||
A | 100 | 98.7 | ||
C | 0 | 1.3 | ||
-308 | ||||
Genotype | ||||
GG | 14(87.5) | 32(86.5) | ||
AG | 2(12.5) | 4(10.8) | 1.14(0.19–6.98) | 0.89 |
AA | 0 | 1(2.7) | 1.44(1.19–1.74)‡ | 0.70 |
Allele | ||||
G | 93.37 | 91.89 | ||
A | 6.25 | 8.11 | ||
-238 | ||||
Genotype | ||||
GG | 13(81.3) | 33(89.2) | ||
AG | 3(18.7) | 4(10.8) | 1.90(0.37–9.71) | 0.35 |
Allele | ||||
G | 90.62 | 94.59 | ||
A | 9.38 | 5.41 |