Table 6 TNF-α gene polymorphisms and the occurrence of interstitial lung fibrosis in SARS patients
SNP site | Interstitial lung fibrosis(%) | Non-interstitial lung fibrosis(%) | OR* (95%C.I.) | P |
|---|---|---|---|---|
-1031 | ||||
Genotype | ||||
TT | 14(70) | 12(57.1) | ||
CT | 6(30) | 8(38.1) | 0.64(0.17–2.38) | 0.51 |
CC | 0 | 1(4.8) | 1.08(0.93–1.27)‡ | 0.48 |
Allele | ||||
T | 85.00 | 76.19 | ||
C | 15.00 | 23.81 | ||
-863 | ||||
Genotype | ||||
CC | 17(77.3) | 16(72.7) | ||
AC | 5(22.7) | 6(27.3) | 0.78(0.20–3.08) | 0.73 |
Allele | ||||
C | 88.64 | 38 | ||
A | 11.36 | 13.64 | ||
-857 | ||||
Genotype | ||||
CC | 15(68.8) | 17(77.3) | ||
CT | 7(31.8) | 5(22.7) | 1.59(0.42–6.07) | 0.50 |
Allele | ||||
C | 84.09 | 88.64 | ||
T | 15.91 | 11.36 | ||
-572 | ||||
Genotype | ||||
AA | 21(95.5) | 22(100) | ||
AC | 1(4.5) | 0 | 0.96(0.87–1.05)& | 0.50 |
Allele | ||||
A | 97.73 | 100.00 | ||
C | 2.27 | 0.00 | ||
-308 | ||||
Genotype | ||||
GG | 21(95.5) | 18(81.8) | ||
AG | 1(4.5) | 4(18.2) | 0.21(0.02–2.10) | 0.17 |
Allele | ||||
G | 97.73 | 90.9 | ||
A | 2.27 | 9.1 | ||
-238 | ||||
Genotype | ||||
GG | 20(90.9) | 18(81.8) | ||
AG | 2(9.1) | 4(18.2) | 0.45(0.07–2.76) | 0.33 |
Allele | ||||
G | 95.45 | 90.9 | ||
A | 4.55 | 9.1 |