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Table 3 TNF-α gene polymorphism and the progress of SARS

From: Roles of TNF-α gene polymorphisms in the occurrence and progress of SARS-Cov infection: A case-control study

SNP site

Severe SARS(%)

Light SARS(%)

OR* (95%CI)

P

-1031

    

   Genotype

    

TT

13(61.9)

22(73.3)

  

CT

7(33.3)

8(26.7)

1.48(0.44–5.04)

0.53

CC

1(4.8)

0(0.0)

2.69(1.75–4.14)&

0.39

   Allele

    

T

78.6

86.7

  

C

21.4

13.3

  

-863

    

   Genotype

    

CC

19(79.2)

24(80.0)

  

AC

5(20.8)

6(20.0)

1.05(0.28–3.98)

0.60

   Allele

    

C

89.6

90.0

  

A

10.4

10.0

  

-857

    

   Genotype

    

CC

15(62.5)

24(80.0)

  

CT

9(37.5)

6(20.0)

2.40(0.71–8.11)

0.15

   Allele

    

C

39(81.2)

54(90.0)

  

T

9(18.8)

6(10.0)

  

-572

    

   Genotype

    

AA

24(100.0)

29(96.7)

  

AC

0(0.0)

1(3.3)

1.83(1.43–2.34)

1.00

   Allele

    

A

100.0

98.3

  

C

0.0

1.7

  

-308

    

   Genotype

    

GG

20(83.3)

27(90.0)

  

AG

4(16.7)

2(6.7)

2.70(0.45–16.22)

0.39

AA

0(0.0)

1(3.3)

1.74(1.36–2.23)$

1.00

   Allele

    

G

100.0

93.3

  

A

0.0

6.7

  

-238

    

   Genotype

    

GG

20(83.3)

27(90.0)

  

AG

4(16.7)

3(10.0)

1.80(0.36–8.96)

0.69

   Allele

    

G

91.70

95.0

  

A

8.3

5.0

  

-204

    

   Genotype

    

TT

24(100.0)

30(100.0)

  

   Allele

    

T

100.0

100.0

  

-163

    

   Genotype

    

GG

24(100.0)

30(100.0)

  

   Allele

    

G

100.0

100.0

  
  1. Note:*: OR was calculated using light SARS as control.
  2. &: Odds ratio replaced with severity SARS group;
  3. $: Odds ratio replaced with light SARS