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Table 2 Effect of ARV therapy on plasma viral load levels after 6, 12 and 24 months.

From: Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: Analysis of the HIV-2 Belgium and Luxembourg database

   Baseline VL VL 6 m VL 12 m VL 24 m Baseline CD4 Delta CD4 12 m
PI-containing regimens
1 AZT-3TC-LPV/r 3.65 U U U 40 + 323
2 d4T-3TC-IDV/r 2.36 U U U 490 + 231
3 d4T-ABC-LPV/r 5.36 D D D 338 +180
4 3TC-TDF-SQV-ATV/r 5.73 U U NA 92 +161
5 d4T-3TC-NFV 3.36 U U U 261 +147
6 TDF-FTC-ATV/r 5.40 D NA NA 10 +140
7 AZT-3TC-LPV/r 4.05 U U U 62 +136
8 d4T-3TC-IDV NA NA NA NA 527 + 89
9 d4T-3TC-LPV/r 4.36 U U U 128 + 67
10 ddI-TDF-IDV/r 3.60 D U NA 120 + 50
11 d4T-3TC-NFV 4.36 D D D 380 + 49
12 AZT-3TC-FPV/r 3.49 D D NA 290 + 40
13 AZT-3TC-IDV 5.29 U U D 280 + 21
14 d4T-3TC-NFV 4.36 D D NA 257 - 14
15 3TC-TDF-IDV/r 2.40 D D NA 180 - 31
  Mean 4.13     230 +106
  Median 4.21     257 +89
PI-sparing regimens
16 AZT-3TC-ABC 3.01 D D D 150 + 57
17 d4T-3TC-ABC-TDF 3.36 U U U 630 +12
18 ddI-TDF-ABC 4.05 D D D 174 - 8
19 AZT-3TC-ABC 5.07 D D NA 166 - 53
20 AZT-3TC-ABC 2.40 D NA NA 737 - 60
21 3TC-ABC-TDF 3.36 NA D NA 195 - 61
22 AZT-3TC-ABC 4,78 D D D 280 - 62
  Mean 3.72     333 -25
  Median 3.36     195 .53
Regimens not included in the comparison above
23 AZT-3TC-NVP NNRTI is not active, suboptimal bitherapy      
24 AZT Suboptimal monotherapy      
25 ddI-d4T-EFV NNRTI is not active, suboptimal bitherapy      
26 AZT-3TC-NFV Therapy switched after 1 month      
27 3TC-ABC-FPV/r Therapy switched after 1 month      
28 AZT-3TC-SQV/r Therapy started end of 2006      
29 AZT-3TC-LPV/r Therapy started end of 2006      
30 AZT Pregnancy, prevention MTCT      
31 AZT Pregnancy, prevention MTCT      
32 AZT-3TC-LPV/r Pregnancy, prevention MTCT      
33 3TC-d4T Lost to follow-up      
34 ddI-d4T-ABC-SQV-NFV Lost to follow-up      
  1. Regimens were classified within the PI-containing and PI-sparing groups from the highest to the lowest delta CD4 counts after 12 months of therapy.
  2. Baseline viral load levels are expressed in log copies/ml of plasma, CD4 counts are expressed in cells/mm3.
  3. All regimens are first line therapies, except regimens 3, 4, 7 and 18 to 22 which are second line therapies; 6, 10, 17, 21 are third line therapies and 15 is a fourth line therapy.
  4. U = undetectable plasma viral load; D = detectable viral load; NA = not available (unavailable sample or end of the treatment); MTCT = mother to child transmission.
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BMC Infectious Diseases

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