Table 2 Summary of predictive value of immunologic characteristics for declines in CD4+ cell counts to < 350/μL in HIV-infected patients after treatment interruption.
From: Immunological predictors of CD4+T cell decline in antiretroviral treatment interruptions
Predictive markers | RR (CI95%) | p-values |
|---|---|---|
CD4 + (cells/μL) nadir | 0.99 (0.99; 1.01) | 0.203 |
CD4+ (cells/μL) nadir < 200/μL | 3.37 (1.07; 10.36) | 0.038 |
CD4 + (cells/μL) at starting HAART | 0.99 (0.99; 1.01) | 0.192 |
CD4+ (cells/μL) at starting HAART < 500/μL | 2.39 (0.86; 6.61) | 0.092 |
CD4 + (cells/μL) baseline | 0.99 (0.99; 1.00) | 0.015 |
CD4+ (cells/μL) at baseline < 750/μL | 3.8 (1.28; 11.25) | 0.016 |
LPR to PPD (per 1000 c.p.m.) baseline | 0.95 (0.91; 1.00) | 0.050 |
LPR to PPD < 10000 c.p.m. | 4.77 (1.07; 21.12) | 0.039 |
IL-4 with PPD stimulus (per 100 pg/mL) baseline | 1.41 (1.01; 1.98) | 0.045 |
IL-4 with PPD stimulus > 100 pg/mL | 5.95 (1.76; 20.07) | 0.004 |
IL-4 with p24 antigen stimulus (per 100 pg/mL) baseline | 1.25 (1.01; 1.55) | 0.039 |
IL-4 with p24 antigen stimulus > 100 pg/mL | 3.14 (0.97; 10.15) | 0.056 |