Figure 3
Decay of (A) productively infected cells (total number of cells) for different degrees of viral infectivity under optimal suppression (β HAART <β crit ) of replication by HAART (r = 0 and 0.95 β crit /β untreated ) for different values of δ U (= 0.02 day-1 and 0.10 day-1). Decay of productively infected cells for different degrees of viral infectivity under sub-optimal suppression (β HAART > β crit ) by HAART for (B) δ U = 0.02 day-1 where β crit /β untreated ≈ 0.769 and (C) δ U = 0.20 day-1 where β crit /β untreated ≈ 0.970 (D) Clinically observed decay of viral load after initiation of HAART for 2 HIV+ patients with no history of drug resistance: pt. 135 (blue) and pt. 140 (red). Pt. 135's viral load has remained undetectable for an additional 5 years with only 1 blip and pt. 140's viral load has remained undetectable for 1 additional year (data not shown). Open faced markers represent undetectable viral load measurements at the limit of detection for the assay used. (E) Decay of latently infected cells (total number of cells) for different degrees of viral infectivity, where β crit /β untreated ≈ 0.769. All simulations were performed with model parameter values listed in Table 1 unless otherwise specified.