ATL313 affects circulating white blood cells. ATL313 (black circle) increases concentrations of circulating white blood cells in mice (N = 6 per group) after inoculation with LPS from E. coli (O111:B4, 5 mg/kg) (A). Additionally, circulating neutrophil (PMN) concentrations are also increased in mice treated with ATL313 (black circle) after LPS inoculation (B). Mean ± standard error of the mean concentrations are shown in K/μL. The difference in concentrations is significantly different at t = 2 hours for both total WBC and PMN concentrations (* WBC p = 0.003; PMN p = 0.007).