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Table 3 Impact of patient characteristics on outcomes measured

From: Epidemiology and outcomes of community-onset methicillin-susceptible Staphylococcus aureusbacteraemia in a university hospital in Singapore

Characteristic Complicated bacteraemia Attributable mortality Complicated and/or recurrent infection
  Odds ratio [CI] p-value Odds ratio [CI] p-value Odds ratio [CI] p-value
Demographics:       
Age > 65 years 1.39 [0.59–3.24] 0.45 13.70 [2.75–68.29] < 0.01 0.48 [0.19–1.22] 0.12
Male gender 0.82 [0.36–1.88] 0.64 1.07 [0.29–3.94] 0.92 1.01 [0.43–2.36] 0.98
Ethnicity 1.59 [0.95–2.64] 0.08 1.10 [0.52–2.36] 0.80 1.73 [1.03–2.90] 0.04
Healthcare-associated infection 0.51 [0.23–1.14] 0.10 1.34 [0.38–4.72] 0.65 0.43 [0.19–1.00] 0.05
Co-morbidities:       
Diabetes mellitus 0.55 [0.24–1.25] 0.15 0.58 [0.14–2.33] 0.44 0.68 [0.29–1.60] 0.38
Dialysis-dependent renal failure 0.71 [0.32–1.57] 0.40 3.27 [0.81–13.13] 0.10 0.36 [0.15–0.84] 0.02
Malignancy 0.42 [0.12–1.44] 0.17 2.66 [0.61–11.56] 0.19 0.24 [0.05–1.15] 0.08
Chronic pulmonary disease 1.88 [0.50–7.10] 0.36 14.00 [3.15–62.17] < 0.01 0.17 [0.02–1.37] 0.10
Valvular heart disease 5.47 [1.10–27.25] 0.04 2.25 [0.41–12.26] 0.35 2.85 [0.75–10.88] 0.12
Other risk factors:       
Intravenous drug abuse 4.92 [1.48–16.41] < 0.01 -* -* 7.99 [2.37–26.98] < 0.01
Presence of intravenous catheter 0.53 [0.21–1.34] 0.18 2.70 [0.75–9.74] 0.14 0.31 [0.11–0.92] 0.03
Previous hospitalization 0.68 [0.31–1.50] 0.34 2.61 [0.65–10.47] 0.18 0.54 [0.24–1.22] 0.14
Inappropriate empiric therapy 0.57 [0.10–3.25] 0.55 4.72 [0.75–29.5] 0.10 -* -*
Suboptimal therapy Not applicable - 2.91 [0.82–10.37] 0.10 Not applicable -
  1. * This calculation predicted failure in a significant way. No intravenous drug abuser died from S. aureus bacteremia, and none of the patients with complicated and/or recurrent infections received inappropriate empiric therapy.