Differences between naive and memory T cell phenotype in Malawian and UK adolescents: a role for Cytomegalovirus?

BMC Infectious Diseases

Table 3 Mean percentages of naïve and memory T cells in 12–15 year old CMV seronegative and seropositive UK adolescents.

		CD4+		CD8+		p value
		CMV seronegative	CMV seropositive	CMV seronegative	CMV seropositive	CD4⁺	CD8⁺
		n = 19	n = 10	n = 19	n = 10
%CCR7 na&#239ve (i.e. CD45RA⁺CCR7⁺)^a	(range)	46 (2–79)	34 (1–57)	60 (43–87)	40 (15–58)	0.14	<0.001
%CCR7 memory that are central memory (i.e. CD45RA^-CCR7⁺)^b	(range)	54 (2–90)	41 (19–74)	32 (0–73)	14 (1–36)	0.16	0.021
%CCR7 memory that are effector memory (i.e. CD45RA^-CCR7^-)^c	(range)	26 (4–45)	35 (20–50)	27 (0–48)	33 (10–56)	0.06	0.27
%CCR7 memory that are stable memory (i.e. CD45RA⁺CCR7^-)^d	(range)	21 (0–95)	24 (0–56)	41 (15–100)	52 (9–83)	0.72	0.21
		n = 18	n = 9	n = 15	n = 11
% "truly naïve"	(range)	75 (55–87)	69 (57–77)	63 (28–80)	51 (39–66)	0.06	0.02
		n = 18	n = 11	n = 18	n = 11
% CD28^-memory (CD28^-CD45RO⁺) T cells	(range)	0.2 (0–0.9)	0.7 (0–2.6)	2.5 (0.4–8.1)	4.4 (0–12.4)	0.03	0.19

Ranges are minimum and maximum values.
^a Proportion of all CCR7 cells that are naïve. ^{b, c, d} Of the CCR7 cells that are memory, proportion that are either central memory (b), effector memory (c) or stable memory (d) (percentages in b, c and d sum to 100).

ISSN: 1471-2334