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Table 1 Gene identified to be highly significantly regulated by B. anthracis

From: Activity of the Bacillus anthracis20 kDa protective antigen component

Gene/protein Donor 1 Donor 2 Donor 3 Donor 4
6-pyruvoyltetrahydropterin synthase 2.265 0.4394 2.262 2.789
acid phosphatase 1, soluble 1.845 2.053 0.8392 3.292
actin, beta -1.667 -2.469 -1.813 -0.7812
adenylate kinase 1 0.1362 0.4168 0.1217 0.406
alcohol dehydrogenase 1C (class I), gamma polypeptide -0.4945 -1.479 -1.452 -0.522
associated molecule with the SH3 domain of STAM (AMSH) like pro -1.286 -0.7072 -1.122 -0.319
AT rich interactive domain 5A (MRF1-like) -1.117 -1.173 -0.608 -0.7124
ATPase, aminophospholipid transporter (APLT), Class I, type 8A, m -0.867 -0.9902 -1.217 -1.002
ATPase, Ca++ transporting, plasma membrane 2 -1.185 -0.8227 -1.454 -1.233
ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d isoform 1 -1.254 -0.7821 -0.7238 -0.1514
ATPase, Na+/K+ transporting, alpha 3 polypeptide -0.5454 -1.172 -1.408 -0.5249
ATP-binding cassette, sub-family A (ABC1), member 3 -0.7075 -1.336 -0.9859 -0.3627
beta-transducin repeat containing -1.301 -1.458 -1.57 -0.5347
bromodomain and PHD finger containing, 3 -0.6459 -0.2634 -1.069 -0.3741
C1q and tumor necrosis factor related protein 1 1.072 1.119 0.9826 0.543
calsyntenin 3 -0.9132 -0.3774 -1.219 -0.3527
calumenin 0.8976 1.009 0.984 1.217
carbonic anhydrase X 1.494 1.533 1.664 0.2302
carcinoembryonic antigen-related cell adhesion molecule 7 0.5028 0.263 0.2265 0.2129
cathepsin D (lysosomal aspartyl protease) -0.4152 -0.3937 -1.185 -0.9571
CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 1.8 1.456 2.398 2.843
CDNA FLJ45814 fis, clone NT2RP7018126 -0.7894 -1.97 -1.454 -0.923
centrin, EF-hand protein, 2 -0.8196 -2.365 -2.736 -1.134
chemokine (C-C motif) receptor 6 -0.4528 -0.2879 -0.6378 -0.2152
Clone IMAGE:4838790, mRNA -0.485 -0.9604 -0.515 -0.2199
cofactor required for Sp1 transcriptional activation, subunit 9, 33 kDa -0.8153 -0.4039 -1.577 -0.6495
complement component 3a receptor 1 -0.7288 -1.094 -1.152 -0.2907
dehydrogenase/reductase (SDR family) member 6 2.449 0.2412 2.836 2.234
DKFZP434P1750 protein -0.9027 -1.021 -0.6581 -0.8601
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 -0.7681 -1.55 -0.7539 -0.2911
ecotropic viral integration site 2B 0.7891 1.913 1.367 1.481
ELYS transcription factor-like protein TMBS62 0.7329 1.34 1.167 0.4772
endothelin receptor type B -0.7971 -0.6776 -1.425 -0.9299
ERO1-like (S. cerevisiae) -0.4751 -1.573 -2.013 -1.192
EST365748 MAGE resequences, MAGC Homo sapiens cDNA, mR -0.3974 -0.9129 -0.9105 -0.3948
eukaryotic translation initiation factor 4E binding protein 1 -0.6047 -1.043 -1.089 -1.082
family with sequence similarity 20, member A -0.26 -0.5113 -1.164 -1.137
F-box and leucine-rich repeat protein 7 2.838 1.484 1.225 3.888
fibronectin 1 -0.5673 -0.5845 -1.167 -1.708
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously 0.7983 1.141 0.7866 0.9328
FLJ20793 protein -0.9689 -0.9124 -1.154 -0.2331
formin-like 1 -0.8158 -1.599 -0.7554 -0.7411
GA binding protein transcription factor, alpha subunit 60 kDa -0.7418 -0.5199 -0.7053 -1.07
galactokinase 1 -0.1951 -0.4303 -0.27 -0.6901
gap junction protein, beta 5 (connexin 31.1) 1.095 1.524 0.9336 0.2265
GLE1 RNA export mediator-like (yeast) -0.8643 -0.341 -0.2584 -0.6748
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme 2.377 1.534 2.844 1.225
GNAS complex locus -0.6085 -1.294 -1.715 -1.55
GRO3 oncogene -0.3814 -1.003 -0.9765 -0.7961
growth factor independent 1 1.282 0.2066 0.669 0.7891
growth hormone receptor -0.3103 -1.458 -0.8417 -1.296
H. sapiens ARS gene, component B. 0.3962 1.059 1.186 0.6116
heat shock 27 kDa protein 2 -0.6707 -0.7274 -2.224 -1.424
hemoglobin, zeta -0.4909 -0.8871 -0.4189 -0.149
high-mobility group 20A 1.768 2.038 0.7883 0.5271
Homo sapiens IGHG3 gene for immunoglobulin heavy chain gamma 1.585 1.946 1.511 1.761
Homo sapiens, clone IMAGE:3954961, mRNA, -1.437 -1.642 -0.8906 -1.996
HSPC135 protein 1.058 1.879 0.8552 0.5993
Human DNA sequence from clone XX-D88L2 on chromosome 1q32 -0.9986 -0.4828 -0.7607 -0.2225
hydroxysteroid (17-beta) dehydrogenase 2 -0.6315 -0.6454 -1.138 -0.4903
hypothetical LOC387763 1.165 0.827 0.3265 1.563
hypothetical protein FLJ10925 -1.163 -0.301 -1.229 -1.046
hypothetical protein FLJ12649 -1.138 -1.602 -1.002 -0.6636
hypothetical protein FLJ31842 -0.7517 -0.2782 -0.436 -0.1725
hypothetical protein IMPACT 0.7924 2.146 1.185 0.512
hypothetical protein LOC51321 -1.431 -0.7981 -0.5971 -0.5105
hypothetical protein MGC2655 3.033 1.669 0.7908 1.584
integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associate -1.358 -1.034 -0.7394 -0.4935
interleukin 6 (interferon, beta 2) -0.9922 -2.6 -1.892 -1.956
kallikrein 10 -0.7654 -0.3185 -1.353 -0.901
keratin, cuticle, ultrahigh sulphur 1 -1.208 -1.486 -1.002 -0.6479
KIAA0195 gene product -0.654 -2.765 -1.988 -1.192
KIAA0196 gene product -1.305 -1.098 -0.8417 -0.8635
KIAA0528 gene product 4.307 2.866 2.187 0.6229
KIAA0759 -0.8301 -0.759 -0.9988 -0.5301
KIAA1458 protein -1.232 -1.82 -0.9504 -0.4043
KIAA1539 -1.079 -1.772 -1.397 -0.9942
kinesin family member 4A -1.135 -1.455 -0.8039 -0.2817
kinetochore associated 2 -0.4972 -1.001 -1.011 -0.7954
kruppel-like zinc finger protein; Homo sapiens promyelocytic leukem -1.251 -0.9379 -1.973 -1.031
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -0.5685 -1.132 -1.798 -0.8039
LOC388610 (LOC388610), mRNA 2.319 0.3752 1.057 2.013
male sterility domain containing 1 -0.6454 -0.5462 -1.525 -1.041
matrix metalloproteinase 16 (membrane-inserted) -1.777 -2.344 -1.65 -0.6869
mesothelin 1.045 1.22 1.54 0.1712
methylthioadenosine phosphorylase -1.51 -0.4183 -1.556 -1.119
mitochondrial ribosomal protein L44 1.706 1.743 0.4926 0.544
molybdenum cofactor synthesis 3 0.779 1.529 0.7891 0.2762
MRNA; cDNA DKFZp686H1039 (from clone DKFZp686H1039) 1.206 0.519 0.9084 1.165
mucin 5, subtype B, tracheobronchial -0.5146 -0.1101 -0.5376 -0.7425
Notch homolog 4 (Drosophila) 0.9252 1.024 0.1454 0.6285
nuclear receptor subfamily 1, group H, member 2 -0.3397 -1.337 -0.9731 -0.5515
paired box gene 3 (Waardenburg syndrome -0.6751 -0.4723 -0.6409 -0.6302
paraneoplastic antigen MA1 -0.67 -1.225 -0.48 -0.2581
PDZ and LIM domain 1 (elfin) 1.041 1.555 0.6517 1.342
peripheral myelin protein 22 -0.4552 -1.767 -1.706 -1.176
PFTAIRE protein kinase 1 -0.5164 -2 -2.035 -1.931
phosphatidylinositol glycan, class Q 1.067 1.114 1.141 0.3068
phytanoyl-CoA hydroxylase interacting protein -1.698 -0.07415 -1.755 -1.699
PlSC domain containing hypothetical protein -1.719 -0.4816 -1.777 -1.5
polymerase (RNA) III (DNA directed) polypeptide G (32 kD) 0.5734 1.622 3.274 3.359
POM (POM121 homolog, rat) and ZP3 fusion -0.647 -0.319 -0.7233 -0.117
potassium inwardly-rectifying channel, subfamily J, member 15 -0.9743 -2.059 -1.175 -0.5925
potassium large conductance calcium-activated channel, subfamily 2.751 1.112 0.5753 1.485
presenilin 2 (Alzheimer disease 4) -0.5609 -1.55 -0.9509 -0.4208
proline-serine-threonine phosphatase interacting protein 1 -0.2379 -0.5739 -0.8672 -0.4775
ProSAPiP2 protein -0.6497 -0.1215 -0.5855 -0.3364
protocadherin 11 Y-linked 1.474 1.825 1.35 0.5331
putative nucleic acid binding protein RY-1 -1.409 -1.09 -0.5389 -0.4293
putative protein similar to nessy (Drosophila) -0.7926 -0.8206 -0.5677 -0.7377
pyroglutamyl-peptidase I -0.1691 -0.7233 -0.8544 -0.5551
qp73h10.x1 Soares_fetal_lung_NbHL19W Homo sapiens cDNA clo -1.024 -1.686 -1.235 -0.9119
RAB30, member RAS oncogene family -1.838 -2.618 -0.917 -0.7415
RAB9B, member RAS oncogene family 0.2029 0.4147 0.4782 0.3173
RA-regulated nuclear matrix-associated protein -0.9885 -0.276 -0.4191 -0.4208
ras homolog gene family, member C 0.3334 0.346 0.2774 0.5479
REST corepressor 1 -0.2084 -1.375 -2.173 -1.47
retinitis pigmentosa 2 (X-linked recessive) 2.301 1.546 1.339 3.789
retinoblastoma-associated protein 140 -0.3049 -1.424 -1.341 -1.09
retinol binding protein 4, plasma -0.6962 -1.256 -2.234 -1.568
ribosomal protein L23 -1.188 -1.077 -1.345 -0.9045
ribosomal protein S20 -2.379 -2.005 -0.4064 -1.469
RNA (guanine-7-) methyltransferase -0.9669 -0.8633 -1.674 -0.3241
RWD domain containing 2 0.9411 1.362 2.293 2.374
SAM and SH3 domain containing 1 -0.9048 -1.158 -0.9225 -1.106
secretin receptor -0.3857 -2.202 -1.223 -1.245
semenogelin II -0.9479 -0.872 -0.5137 -0.1655
SET translocation (myeloid leukemia-associated) -1.673 -0.5829 -1.633 -0.8802
sideroflexin 1 -0.4931 -0.7209 -0.8337 -0.8135
similar to human GTPase-activating protein -2.076 -1.635 -1.364 -0.8021
Similar to Lysophospholipase -0.9395 -1.975 -0.6778 -0.7481
small nuclear RNA activating complex, polypeptide 5, 19 kDa -1.124 -1.438 -0.372 -0.4988
snail homolog 1 (Drosophila) 1.386 2.22 0.6079 0.8456
solute carrier family 16 (monocarboxylic acid transporters), member -0.8285 -0.8079 -1.113 -0.09096
solute carrier family 34 (sodium phosphate), member 1 -0.2497 -0.9574 -0.6233 -0.55
solute carrier family 4, sodium bicarbonate cotransporter, member 7 1.666 2.241 0.4895 0.9819
somatostatin receptor 2 3.287 1.207 2.095 2.374
sorting nexin 15 -0.5503 -0.7774 -0.4106 -0.3535
SP110 nuclear body protein -0.699 -1.42 -1.406 -0.4606
START domain containing 3 -1.17 -2.012 -1.621 -0.4317
suppressor of var1, 3-like 1 (S. cerevisiae) -1.02 -0.8975 -0.4765 -0.2837
synovial sarcoma, X breakpoint 2 interacting protein 0.9957 1.435 0.8189 0.3763
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associa 1.408 0.8041 1.358 0.5028
TAP binding protein (tapasin) 2.518 1.909 0.3718 1.161
thymus high mobility group box protein TOX 1.165 1.726 1.373 0.3885
toll-like receptor 3 -0.8173 -1.102 -1.35 -0.3895
TRAF and TNF receptor associated protein -1.192 -1.042 -0.7728 -0.1867
Transcribed sequence with strong similarity to protein ref:NP_05761 -1.382 -2.008 -0.7379 -0.4367
Transcribed sequence with weak similarity to protein ref:NP_06031 0.8875 1.208 0.9568 0.2339
Transcribed sequence with weak similarity to protein sp:P39193 (H. -1.096 -1.454 -1.585 -0.1049
Transcribed sequences 0.5241 0.8148 0.8891 1.009
Transcribed sequences -3.77 -2.45 -1.731 -0.6047
tribbles homolog 3 (Drosophila) -0.4489 -1.411 -1.424 -0.4251
troponin I, skeletal, slow -0.2777 -0.7372 -1.637 -1.618
tuberous sclerosis 2 0.7672 1.119 0.3896 1.254
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation -1.402 -1.306 -1.059 -0.2737
upstream regulatory element binding protein 1 -1.067 -1.853 -0.8107 -0.3799
vacuolar protein sorting 33B (yeast) 1.124 0.6897 1.236 1.376
WD and tetratricopeptide repeats 1 -1.529 -0.1551 -1.397 -0.9977
x 006 protein 1.105 1.55 3.65 2.442
X-ray repair complementing defective repair in Chinese hamster cell 0.9716 1.156 0.3796 0.6554
zinc finger and BTB domain containing 26 2.651 1.075 0.7553 1.785
zinc finger protein 23 (KOX 16) 2.372 2.401 0.8906 1.1
zinc finger, DHHC domain containing 18 -0.189 -0.3015 -0.6595 -0.228
zp19d06.s1 Stratagene fetal retina 937202 Homo sapiens cDNA clo 1.479 0.8278 0.384 0.7579