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Table 1 Gene identified to be highly significantly regulated by B. anthracis

From: Activity of the Bacillus anthracis20 kDa protective antigen component

Gene/protein

Donor 1

Donor 2

Donor 3

Donor 4

6-pyruvoyltetrahydropterin synthase

2.265

0.4394

2.262

2.789

acid phosphatase 1, soluble

1.845

2.053

0.8392

3.292

actin, beta

-1.667

-2.469

-1.813

-0.7812

adenylate kinase 1

0.1362

0.4168

0.1217

0.406

alcohol dehydrogenase 1C (class I), gamma polypeptide

-0.4945

-1.479

-1.452

-0.522

associated molecule with the SH3 domain of STAM (AMSH) like pro

-1.286

-0.7072

-1.122

-0.319

AT rich interactive domain 5A (MRF1-like)

-1.117

-1.173

-0.608

-0.7124

ATPase, aminophospholipid transporter (APLT), Class I, type 8A, m

-0.867

-0.9902

-1.217

-1.002

ATPase, Ca++ transporting, plasma membrane 2

-1.185

-0.8227

-1.454

-1.233

ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d isoform 1

-1.254

-0.7821

-0.7238

-0.1514

ATPase, Na+/K+ transporting, alpha 3 polypeptide

-0.5454

-1.172

-1.408

-0.5249

ATP-binding cassette, sub-family A (ABC1), member 3

-0.7075

-1.336

-0.9859

-0.3627

beta-transducin repeat containing

-1.301

-1.458

-1.57

-0.5347

bromodomain and PHD finger containing, 3

-0.6459

-0.2634

-1.069

-0.3741

C1q and tumor necrosis factor related protein 1

1.072

1.119

0.9826

0.543

calsyntenin 3

-0.9132

-0.3774

-1.219

-0.3527

calumenin

0.8976

1.009

0.984

1.217

carbonic anhydrase X

1.494

1.533

1.664

0.2302

carcinoembryonic antigen-related cell adhesion molecule 7

0.5028

0.263

0.2265

0.2129

cathepsin D (lysosomal aspartyl protease)

-0.4152

-0.3937

-1.185

-0.9571

CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)

1.8

1.456

2.398

2.843

CDNA FLJ45814 fis, clone NT2RP7018126

-0.7894

-1.97

-1.454

-0.923

centrin, EF-hand protein, 2

-0.8196

-2.365

-2.736

-1.134

chemokine (C-C motif) receptor 6

-0.4528

-0.2879

-0.6378

-0.2152

Clone IMAGE:4838790, mRNA

-0.485

-0.9604

-0.515

-0.2199

cofactor required for Sp1 transcriptional activation, subunit 9, 33 kDa

-0.8153

-0.4039

-1.577

-0.6495

complement component 3a receptor 1

-0.7288

-1.094

-1.152

-0.2907

dehydrogenase/reductase (SDR family) member 6

2.449

0.2412

2.836

2.234

DKFZP434P1750 protein

-0.9027

-1.021

-0.6581

-0.8601

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

-0.7681

-1.55

-0.7539

-0.2911

ecotropic viral integration site 2B

0.7891

1.913

1.367

1.481

ELYS transcription factor-like protein TMBS62

0.7329

1.34

1.167

0.4772

endothelin receptor type B

-0.7971

-0.6776

-1.425

-0.9299

ERO1-like (S. cerevisiae)

-0.4751

-1.573

-2.013

-1.192

EST365748 MAGE resequences, MAGC Homo sapiens cDNA, mR

-0.3974

-0.9129

-0.9105

-0.3948

eukaryotic translation initiation factor 4E binding protein 1

-0.6047

-1.043

-1.089

-1.082

family with sequence similarity 20, member A

-0.26

-0.5113

-1.164

-1.137

F-box and leucine-rich repeat protein 7

2.838

1.484

1.225

3.888

fibronectin 1

-0.5673

-0.5845

-1.167

-1.708

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously

0.7983

1.141

0.7866

0.9328

FLJ20793 protein

-0.9689

-0.9124

-1.154

-0.2331

formin-like 1

-0.8158

-1.599

-0.7554

-0.7411

GA binding protein transcription factor, alpha subunit 60 kDa

-0.7418

-0.5199

-0.7053

-1.07

galactokinase 1

-0.1951

-0.4303

-0.27

-0.6901

gap junction protein, beta 5 (connexin 31.1)

1.095

1.524

0.9336

0.2265

GLE1 RNA export mediator-like (yeast)

-0.8643

-0.341

-0.2584

-0.6748

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme

2.377

1.534

2.844

1.225

GNAS complex locus

-0.6085

-1.294

-1.715

-1.55

GRO3 oncogene

-0.3814

-1.003

-0.9765

-0.7961

growth factor independent 1

1.282

0.2066

0.669

0.7891

growth hormone receptor

-0.3103

-1.458

-0.8417

-1.296

H. sapiens ARS gene, component B.

0.3962

1.059

1.186

0.6116

heat shock 27 kDa protein 2

-0.6707

-0.7274

-2.224

-1.424

hemoglobin, zeta

-0.4909

-0.8871

-0.4189

-0.149

high-mobility group 20A

1.768

2.038

0.7883

0.5271

Homo sapiens IGHG3 gene for immunoglobulin heavy chain gamma

1.585

1.946

1.511

1.761

Homo sapiens, clone IMAGE:3954961, mRNA,

-1.437

-1.642

-0.8906

-1.996

HSPC135 protein

1.058

1.879

0.8552

0.5993

Human DNA sequence from clone XX-D88L2 on chromosome 1q32

-0.9986

-0.4828

-0.7607

-0.2225

hydroxysteroid (17-beta) dehydrogenase 2

-0.6315

-0.6454

-1.138

-0.4903

hypothetical LOC387763

1.165

0.827

0.3265

1.563

hypothetical protein FLJ10925

-1.163

-0.301

-1.229

-1.046

hypothetical protein FLJ12649

-1.138

-1.602

-1.002

-0.6636

hypothetical protein FLJ31842

-0.7517

-0.2782

-0.436

-0.1725

hypothetical protein IMPACT

0.7924

2.146

1.185

0.512

hypothetical protein LOC51321

-1.431

-0.7981

-0.5971

-0.5105

hypothetical protein MGC2655

3.033

1.669

0.7908

1.584

integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associate

-1.358

-1.034

-0.7394

-0.4935

interleukin 6 (interferon, beta 2)

-0.9922

-2.6

-1.892

-1.956

kallikrein 10

-0.7654

-0.3185

-1.353

-0.901

keratin, cuticle, ultrahigh sulphur 1

-1.208

-1.486

-1.002

-0.6479

KIAA0195 gene product

-0.654

-2.765

-1.988

-1.192

KIAA0196 gene product

-1.305

-1.098

-0.8417

-0.8635

KIAA0528 gene product

4.307

2.866

2.187

0.6229

KIAA0759

-0.8301

-0.759

-0.9988

-0.5301

KIAA1458 protein

-1.232

-1.82

-0.9504

-0.4043

KIAA1539

-1.079

-1.772

-1.397

-0.9942

kinesin family member 4A

-1.135

-1.455

-0.8039

-0.2817

kinetochore associated 2

-0.4972

-1.001

-1.011

-0.7954

kruppel-like zinc finger protein; Homo sapiens promyelocytic leukem

-1.251

-0.9379

-1.973

-1.031

kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)

-0.5685

-1.132

-1.798

-0.8039

LOC388610 (LOC388610), mRNA

2.319

0.3752

1.057

2.013

male sterility domain containing 1

-0.6454

-0.5462

-1.525

-1.041

matrix metalloproteinase 16 (membrane-inserted)

-1.777

-2.344

-1.65

-0.6869

mesothelin

1.045

1.22

1.54

0.1712

methylthioadenosine phosphorylase

-1.51

-0.4183

-1.556

-1.119

mitochondrial ribosomal protein L44

1.706

1.743

0.4926

0.544

molybdenum cofactor synthesis 3

0.779

1.529

0.7891

0.2762

MRNA; cDNA DKFZp686H1039 (from clone DKFZp686H1039)

1.206

0.519

0.9084

1.165

mucin 5, subtype B, tracheobronchial

-0.5146

-0.1101

-0.5376

-0.7425

Notch homolog 4 (Drosophila)

0.9252

1.024

0.1454

0.6285

nuclear receptor subfamily 1, group H, member 2

-0.3397

-1.337

-0.9731

-0.5515

paired box gene 3 (Waardenburg syndrome

-0.6751

-0.4723

-0.6409

-0.6302

paraneoplastic antigen MA1

-0.67

-1.225

-0.48

-0.2581

PDZ and LIM domain 1 (elfin)

1.041

1.555

0.6517

1.342

peripheral myelin protein 22

-0.4552

-1.767

-1.706

-1.176

PFTAIRE protein kinase 1

-0.5164

-2

-2.035

-1.931

phosphatidylinositol glycan, class Q

1.067

1.114

1.141

0.3068

phytanoyl-CoA hydroxylase interacting protein

-1.698

-0.07415

-1.755

-1.699

PlSC domain containing hypothetical protein

-1.719

-0.4816

-1.777

-1.5

polymerase (RNA) III (DNA directed) polypeptide G (32 kD)

0.5734

1.622

3.274

3.359

POM (POM121 homolog, rat) and ZP3 fusion

-0.647

-0.319

-0.7233

-0.117

potassium inwardly-rectifying channel, subfamily J, member 15

-0.9743

-2.059

-1.175

-0.5925

potassium large conductance calcium-activated channel, subfamily

2.751

1.112

0.5753

1.485

presenilin 2 (Alzheimer disease 4)

-0.5609

-1.55

-0.9509

-0.4208

proline-serine-threonine phosphatase interacting protein 1

-0.2379

-0.5739

-0.8672

-0.4775

ProSAPiP2 protein

-0.6497

-0.1215

-0.5855

-0.3364

protocadherin 11 Y-linked

1.474

1.825

1.35

0.5331

putative nucleic acid binding protein RY-1

-1.409

-1.09

-0.5389

-0.4293

putative protein similar to nessy (Drosophila)

-0.7926

-0.8206

-0.5677

-0.7377

pyroglutamyl-peptidase I

-0.1691

-0.7233

-0.8544

-0.5551

qp73h10.x1 Soares_fetal_lung_NbHL19W Homo sapiens cDNA clo

-1.024

-1.686

-1.235

-0.9119

RAB30, member RAS oncogene family

-1.838

-2.618

-0.917

-0.7415

RAB9B, member RAS oncogene family

0.2029

0.4147

0.4782

0.3173

RA-regulated nuclear matrix-associated protein

-0.9885

-0.276

-0.4191

-0.4208

ras homolog gene family, member C

0.3334

0.346

0.2774

0.5479

REST corepressor 1

-0.2084

-1.375

-2.173

-1.47

retinitis pigmentosa 2 (X-linked recessive)

2.301

1.546

1.339

3.789

retinoblastoma-associated protein 140

-0.3049

-1.424

-1.341

-1.09

retinol binding protein 4, plasma

-0.6962

-1.256

-2.234

-1.568

ribosomal protein L23

-1.188

-1.077

-1.345

-0.9045

ribosomal protein S20

-2.379

-2.005

-0.4064

-1.469

RNA (guanine-7-) methyltransferase

-0.9669

-0.8633

-1.674

-0.3241

RWD domain containing 2

0.9411

1.362

2.293

2.374

SAM and SH3 domain containing 1

-0.9048

-1.158

-0.9225

-1.106

secretin receptor

-0.3857

-2.202

-1.223

-1.245

semenogelin II

-0.9479

-0.872

-0.5137

-0.1655

SET translocation (myeloid leukemia-associated)

-1.673

-0.5829

-1.633

-0.8802

sideroflexin 1

-0.4931

-0.7209

-0.8337

-0.8135

similar to human GTPase-activating protein

-2.076

-1.635

-1.364

-0.8021

Similar to Lysophospholipase

-0.9395

-1.975

-0.6778

-0.7481

small nuclear RNA activating complex, polypeptide 5, 19 kDa

-1.124

-1.438

-0.372

-0.4988

snail homolog 1 (Drosophila)

1.386

2.22

0.6079

0.8456

solute carrier family 16 (monocarboxylic acid transporters), member

-0.8285

-0.8079

-1.113

-0.09096

solute carrier family 34 (sodium phosphate), member 1

-0.2497

-0.9574

-0.6233

-0.55

solute carrier family 4, sodium bicarbonate cotransporter, member 7

1.666

2.241

0.4895

0.9819

somatostatin receptor 2

3.287

1.207

2.095

2.374

sorting nexin 15

-0.5503

-0.7774

-0.4106

-0.3535

SP110 nuclear body protein

-0.699

-1.42

-1.406

-0.4606

START domain containing 3

-1.17

-2.012

-1.621

-0.4317

suppressor of var1, 3-like 1 (S. cerevisiae)

-1.02

-0.8975

-0.4765

-0.2837

synovial sarcoma, X breakpoint 2 interacting protein

0.9957

1.435

0.8189

0.3763

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associa

1.408

0.8041

1.358

0.5028

TAP binding protein (tapasin)

2.518

1.909

0.3718

1.161

thymus high mobility group box protein TOX

1.165

1.726

1.373

0.3885

toll-like receptor 3

-0.8173

-1.102

-1.35

-0.3895

TRAF and TNF receptor associated protein

-1.192

-1.042

-0.7728

-0.1867

Transcribed sequence with strong similarity to protein ref:NP_05761

-1.382

-2.008

-0.7379

-0.4367

Transcribed sequence with weak similarity to protein ref:NP_06031

0.8875

1.208

0.9568

0.2339

Transcribed sequence with weak similarity to protein sp:P39193 (H.

-1.096

-1.454

-1.585

-0.1049

Transcribed sequences

0.5241

0.8148

0.8891

1.009

Transcribed sequences

-3.77

-2.45

-1.731

-0.6047

tribbles homolog 3 (Drosophila)

-0.4489

-1.411

-1.424

-0.4251

troponin I, skeletal, slow

-0.2777

-0.7372

-1.637

-1.618

tuberous sclerosis 2

0.7672

1.119

0.3896

1.254

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation

-1.402

-1.306

-1.059

-0.2737

upstream regulatory element binding protein 1

-1.067

-1.853

-0.8107

-0.3799

vacuolar protein sorting 33B (yeast)

1.124

0.6897

1.236

1.376

WD and tetratricopeptide repeats 1

-1.529

-0.1551

-1.397

-0.9977

x 006 protein

1.105

1.55

3.65

2.442

X-ray repair complementing defective repair in Chinese hamster cell

0.9716

1.156

0.3796

0.6554

zinc finger and BTB domain containing 26

2.651

1.075

0.7553

1.785

zinc finger protein 23 (KOX 16)

2.372

2.401

0.8906

1.1

zinc finger, DHHC domain containing 18

-0.189

-0.3015

-0.6595

-0.228

zp19d06.s1 Stratagene fetal retina 937202 Homo sapiens cDNA clo

1.479

0.8278

0.384

0.7579