Figure 8
From: Activity of the Bacillus anthracis20 kDa protective antigen component
Expression profile of genes related to the cell adhesion pathway that were up regulated by rPA 20 in PBMC. Cells were incubated with the rPA20 for 4 hrs. RNA samples were isolated and hybridized on the cDNA micorarray slides as detailed in materials and methods. Images were analyzed using GenePix 4.0 and data were analyzed using GeneSpring 7.0. Data were then analyzed using GeneCite to identify pathways regulated by the rPA20. These genes are platelet/endothelial cell adhesion molecule 1 (PECAM1), breast cancer anti-estrogen resistance (BCAR), capping protein (actin filament) muscle Z-line, alpha 1 (F-actin), actinin, alpha 2, catenin alpha and PTK2 protein tyrosine kinase 2 (PTK2).