Table 3 Hepatitis B acquisition and future burden estimates for infants born in government maternity hospitals with current vaccination programming with the DPT series in Kabul, Afghanistan.
Number Without Program | Number With Program | Number Prevented | Percent Reduction | |
|---|---|---|---|---|
A. Disease Events Prevented (Future burden) | ||||
Total HBV infections | 27,054 | 19,735 | 7,319 | 27% |
Acute symptomatic hepatitis B cases | 5,400 | 3,933 | 1,467 | 27% |
Chronic HBV infections | 4,937 | 3,625 | 1,313 | 27% |
HBV-related deaths: | ||||
Acute hepatitis B | 23 | 17 | 6 | 27% |
Cirrhosis | 268 | 197 | 71 | 27% |
Hepatocellular carcinoma | 170 | 125 | 45 | 27% |
Total Deaths | 460 | 338 | 123 | 27% |
B. Number of Infections by Age at Acquisition of Infection (Future burden) | ||||
Perinatal Infection | 117 | 117 | 0 | 0% |
Early Childhood Infection | 13,410 | 9,766 | 3,643 | 27% |
Late Infection | 13,527 | 9,852 | 3,675 | 27% |
Total Infections | 27,054 | 19,735 | 7,319 | 27% |
C. Number of Chronic Infections by Age at Acquisition of Infection (Future burden) | ||||
Perinatal Infection | 106 | 106 | 0 | 0% |
Early Childhood Infection | 4,021 | 2,929 | 1,093 | 27% |
Late Infection | 811 | 590 | 220 | 27% |
Total Infections | 4,937 | 3,625 | 1,313 | 27% |
D. Number of Deaths by Age at Acquisition of Infection (Future burden) | ||||
Perinatal Infection | 9 | 9 | 0 | 0% |
Early Childhood Infection | 362 | 264 | 98 | 27% |
Late Infection | 89 | 65 | 24 | 27% |
Total Deaths | 460 | 338 | 123 | 27% |
Appendix. Input values | ||||
Prevalance HBsAg among women of child bearing age: | 1.3 | |||
Prevalence HBeAg among HBsAg-positive women of child bearing age: | 12.5 | |||
Prevalence of any marker of HBV infection among 5 year olds: | 30 | |||
Prevalence of any marker of HBV infection among 30+ year olds: | 60 | |||
Estimated Hepatitis B3 coverage: | 28.6 | |||
Estimated coverage with birth dose hepatitis B vaccine: | 0 | |||