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Table 3 Predictors of in-hospital mortality for HIV-infected patients with Pneumocystis pneumonia for the entire cohort and according to empiric or definitive diagnosis.

From: Outcome of HIV-associated Pneumocystis pneumonia in hospitalized patients from 2000 through 2003

Univariate predictors All subjects (n = 292) OR (95% CI), p-value Empiric (n = 127) OR (95% CI), p-value Definitive (n = 165) OR (95% CI), p-value
Mechanical ventilation 18.0 (7.9–41.1), < 0.001 86.3 (13.1–568.3), <0.001 9.6 (3.8–24.7), < 0.001
Pneumothorax 10.3 (3.9–27.3), < 0.001 _* 10.2 (3.5–29.7), < 0.001
Serum LDH (per 100 U/l increase) 1.3 (1.09–1.65), 0.005 1.3 (0.79–2.02), 0.33 1.3 (1.02–1.63), 0.03
Serum albumin (per 0.1 g/dl increase) 0.32 (0.17–0.60), < 0.001 0.27 (0.09–0.88), 0.02 0.36 (0.17–0.77), 0.008
Empiric diagnosis 0.36 (0.16–0.82), 0.02 _ _
Alveolar-arterial oxygen gradient (per 1 mm Hg increase)(n = 129) 1.08 (1.03–1.12), 0.001 1.05 (0.98–1.12), p = 0.16 1.10 (1.03–1.17), p = 0.003
Multivariate predictors (n = 278)    
Pneumothorax 15.7 (4.4–56.4), < 0.001   
Mechanical ventilation 14.8 (5.7–38.9), < 0.001   
Serum albumin (per 0.1 g/dl increase) 0.27 (0.12–0.61), 0.002   
  1. Abbreviations: CI, confidence interval; LDH, lactate dehydrogenase; OR, odds ratio.
  2. *Unable to calculate odds ratio because of the small number of occurrences.