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Table 1 Sources, experimental models, and scoring criteria for Mycobacterium tuberculosis DNA microarray gene expression and genome-wide gene knock-out (growth phase essentiality) data used in this study.

From: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections

Reference Experimental model Timepoint: Maximum scorea
Betts et al., 2002 [116] Starvation under controlled O2 96 h: 3
24 h: 2
4 h: 1
Hampshire et al., 2004 [30] Nutrient depletion under controlled O2 62 and 75 d: 5
49 d: 4
18 d: 2
Muttucumaru et al., 2004 [115] Wayne model of hypoxia [8] 14 d (NRP-2): 4
7 d (NRP-1): 2
Voskuil et al. 2004 [31] Wayne model of hypoxia [8] 30 and 80 d: 5
14 and 20 d: 4
10 and 12 d: 3
6 and 8 d: 2
Schnappinger et al. 2003 [29] Infection of mouse macrophages, +/- γ-INF 24 and 48 h: 5
Karakousis et al., 2004 [117] Hollow fiber subcutaneous implant in mice 10 d: 3
Talaat et al., 2004 [118] Infection of mice. MTB harvested from lungb 28 d: 3
Sassetti et al. 2003a [13] TraSH mutated libraries grown on solid media 14 d:5
Rengarajan et al. 2005 [12] Infection of mouse macrophages, +/- γ-INF with TraSH mutated libraries of M. tuberculosis 7 d: 5
Sassetti et al. 2003b [14] C57BL/6J mice infected with TraSH mutated libraries of M. tuberculosis 7, 14, 28 and 56 d: 5
  1. Footnotes
  2. aMaximum score based on relevance as a dormancy model.
  3. bRatio of M. tuberculosis from Balb/c lung to MTB in aerated culture for 28 d.