Table 1 Sources, experimental models, and scoring criteria for Mycobacterium tuberculosis DNA microarray gene expression and genome-wide gene knock-out (growth phase essentiality) data used in this study.
From: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections
Reference | Experimental model | Timepoint: Maximum scorea |
|---|---|---|
Betts et al., 2002 [116] | Starvation under controlled O2 | 96 h: 3 24 h: 2 4 h: 1 |
Hampshire et al., 2004 [30] | Nutrient depletion under controlled O2 | 62 and 75 d: 5 49 d: 4 18 d: 2 |
Muttucumaru et al., 2004 [115] | Wayne model of hypoxia [8] | 14 d (NRP-2): 4 7 d (NRP-1): 2 |
Voskuil et al. 2004 [31] | Wayne model of hypoxia [8] | 30 and 80 d: 5 14 and 20 d: 4 10 and 12 d: 3 6 and 8 d: 2 |
Schnappinger et al. 2003 [29] | Infection of mouse macrophages, +/- γ-INF | 24 and 48 h: 5 |
Karakousis et al., 2004 [117] | Hollow fiber subcutaneous implant in mice | 10 d: 3 |
Talaat et al., 2004 [118] | Infection of mice. MTB harvested from lungb | 28 d: 3 |
Sassetti et al. 2003a [13] | TraSH mutated libraries grown on solid media | 14 d:5 |
Rengarajan et al. 2005 [12] | Infection of mouse macrophages, +/- γ-INF with TraSH mutated libraries of M. tuberculosis | 7 d: 5 |
Sassetti et al. 2003b [14] | C57BL/6J mice infected with TraSH mutated libraries of M. tuberculosis | 7, 14, 28 and 56 d: 5 |