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Table 1 Overall results of the EQA for the serological detection of WN virus infection

From: First international diagnostic accuracy study for the serological detection of West Nile virus infection

  

Sample N°

 

Lab. N°

Assay used

#8 anti-WN

#12 anti-WN

#5 anti-WN

#6 anti-WN

#10 anti-TBE

#7 anti-YF

#11 anti-DEN

#3 neg.

#2 neg.

#1 unspec.

Correct results in %

2‡

EIA/IFAih

(-)/+

(-)/+

(-)/+

-/+

-

-

-

-

-

-

100.0

4

EIAih

+/+

+/+

+/+

-/+

-*

-*

-

-

-

-

100.0

8

EIAih

+/(-)

+/+

+/+

-/+

-

-/e

-

-

-

-

100.0

18

EIAih

+/+

+/+

+/+

-/+

-

-*

-

-

-

-

100.0

29

IFAih

(-)/+

(-)/+

+/+

-/+

-

-*

-

-

-

-

100.0

37

EIAih

+

+

+

+

-

-*

-

-

-

-

100.0

5

EIA F

+/+

e/+

+/+

-/+

-

-/(+)

-

-

-

-

90.0

6

IFAih

(-)/+

(-)/+

+/+

-/+

-

-/(+)

-

-

-

-

90.0

9

IFA P

(-)

(+)/(+)

+/+

-/(+)

-

-*

-

-

-

-

90.0

10

IFAih

(-)/+

(-)

(-)/+

-/+

-

-

-

-

-

-

90.0

14

EIAih

(-)/+

+/+

(-)/+

-/+

-

-/(+)

-

-

-

-

90.0

16

EIA F

+/+

e/+

+/+

-/+

-

-/(+)

-

-

-

-

90.0

17

IFAih

(-)/+

(-)/+

+/+

-/+

-

-/e

-

-

-

-/(+)

90.0

20

EIA F

+/+

e/+

+/+

-/+

-

-/(+)

-

-

-

-

90.0

23

EIA F

(-)/+

(-)/+

(-)/+

-/+

-

-/(+)

-

-

-

-

90.0

35

EIA F+P

e/+

e/+

e/+

-/+

-

-/(+)

-

-

-

-

90.0

11

IFAih

+/+

+/+

+/+

(+)/+

-

-/(+)

-

-

-

(+)

80.0

13

EIA F

+/+

e/+

e/+

-/+

-

-/(+)

(+)/-

-

-

-

80.0

24

EIAih

+

(-)

+

(-)

-

-

-

-

-

-

80.0

25

EIA F

(+)/+

(-)/e

(+)/+

-/+

-

-/(+)

-

-

-

-

80.0

33

EIAih

+

+

+

+

(+)

(+)

-

-

-

-

80.0

15

EIA F

+/+

+/+

+/+

-/+

(+)/-

-/(+)

ind.

-

-

-

77.8

30

EIAih

(-)

(-)

+

+

-

(+)

-

-

-

-

70.0

7

NTih

(+)

(+)

+

+

-

-

-

-

-

-

100.0

36

NTih

e

+

+

+

-

-

-

-

-

-

100.0

11

NTih

+

+

+

(+)

-

-

-

-

-

(+)

90.0

5

NTih

+

+

+

+

-

(+)

(+)

-

-

-

80.0

12

NTih

+

+

+

+

(+)

(+)

-

-

-

-

80.0

39

NTih

(-)

(-)

(+)

(+)

-

-

-

-

-

-

80.0

30

NTih

(-)

(-)

+

+

-

(+)

-

-

-

-

70.0

  1. WN = West Nile; TBE = tick-borne encephalitis; YF = yellow fever; DEN = dengue; neg. = negative; unspec. = unspecific. x/x = IgM/IgG result: - = correct negative result; (-) = false negative result without meaning; + = correct positive result; (+) = weak positive result; e = equivocal result; ind. = indetermined. -* = negative for WN virus, but other flavivirus detected; -# = negative for WN virus, but unspecific reaction detected. Results marked in bold mean false negative/positive results or non conclusive results which may have consequences for the decision of the clinician. ‡ Laboratory reported combined results: IgM tested by EIA and IgG tested by IFA. In other cases laboratories have reported combined results for IgM and IgG (single results).
  2. EIA: Enzyme immunoassay; IFA: Immunofluorescence assay; NT: neutralisation test. Assays marked with the index "ih" are in-house assays. Assays marked in bold are commercial assays. Manufacturers: F = Focus Diagnostics Inc., Cypress, CA; USA, P = PanBio Ltd., Queensland, Australia.
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BMC Infectious Diseases

ISSN: 1471-2334

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