Skip to main content

Table 1 Patient Characteristics

From: Antifungal prophylaxis in chemotherapy-associated neutropenia: a retrospective, observational study

 

AMB Period vs. AZ Period

 

AMB

AZ

Odds Ratio1

p-value

No. of Hospitalizations

259

321

  

No. of Patients

181

216

  

Mean Age2

49.6 yrs (19 – 86 yrs)3

50.3 yrs (18 – 83 yrs)

 

<0.0014

Gender

65% male

55% male

OR = 0.00

0.00095

Diagnoses

    

NHL

74 (29%)

102 (32%)

OR = 0.96

0.97

Hodgkin's Disease

11 (4%)

19 (6%)

OR = 1.38

0.85

Myeloid Neoplasms

96 (37%)

111 (35%)

OR = 0.56

0.6

Lymphocytic Leukemia

46 (18%)

40 (12%)

OR = 0.58

0.66

Multiple Myeloma

25 (10%)

39 (12%)

OR = 1.16

0.9

Other

7 (3%)

10 (3%)

OR = 6.45

0.25

Therapy

    

Mini-transplant

14 (8%)

15 (5%)

OR = 0.98

0.965

Allo-transplant

3 (2%)

23 (7%)

OR = 2.62

0.225

Auto-transplant

39 (22%)

42 (13%)

OR = 0.63

0.035

Chemotherapy

113 (62%)

136 (42%)

OR = 1.16

0.555

Other

11(6%)

19 (6%)

OR = 1.24

0.595

Twin-transplant

1 (0.6%)

0

  

Mean Length of Stay2

20.9 days (19–23 days)

19.2 days (17.5–21.1 days)

 

0.214

Mean Duration of therapy2

19.8 days (17.9–21.8 days)

16.5 days (15–18.1 days)

 

0.0094

  1. 1Odds ratios are from random effects regression models that controlled for the number of hospitalizations. The reported odds ratios are the odds of having the individual variables in the AZ period relative to the AMB period
  2. 2Reported means are least squared means from mixed effects regression models that controlled for the number of hospitalizations
  3. 3age range is the observed age range of the patients in each period
  4. 4p-values are from mixed effects logistic regression models that controlled for the number of hospitalization
  5. 5p-values are from random effects logistic regression models that controlled for the number of hospitalization
  6. Note: AMB = amphotericin; AZ = Azole; FLU = fluconazole; VOR = voriconazole; NHL = non-Hodgkin's lymphoma; OR = odds ratio; Allo-transplant = allogeneic stem cell transplant; auto-transplant = autologous stem cell transplant