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Table 1 Patient Characteristics

From: Antifungal prophylaxis in chemotherapy-associated neutropenia: a retrospective, observational study

  AMB Period vs. AZ Period
  AMB AZ Odds Ratio1 p-value
No. of Hospitalizations 259 321   
No. of Patients 181 216   
Mean Age2 49.6 yrs (19 – 86 yrs)3 50.3 yrs (18 – 83 yrs)   <0.0014
Gender 65% male 55% male OR = 0.00 0.00095
Diagnoses     
NHL 74 (29%) 102 (32%) OR = 0.96 0.97
Hodgkin's Disease 11 (4%) 19 (6%) OR = 1.38 0.85
Myeloid Neoplasms 96 (37%) 111 (35%) OR = 0.56 0.6
Lymphocytic Leukemia 46 (18%) 40 (12%) OR = 0.58 0.66
Multiple Myeloma 25 (10%) 39 (12%) OR = 1.16 0.9
Other 7 (3%) 10 (3%) OR = 6.45 0.25
Therapy     
Mini-transplant 14 (8%) 15 (5%) OR = 0.98 0.965
Allo-transplant 3 (2%) 23 (7%) OR = 2.62 0.225
Auto-transplant 39 (22%) 42 (13%) OR = 0.63 0.035
Chemotherapy 113 (62%) 136 (42%) OR = 1.16 0.555
Other 11(6%) 19 (6%) OR = 1.24 0.595
Twin-transplant 1 (0.6%) 0   
Mean Length of Stay2 20.9 days (19–23 days) 19.2 days (17.5–21.1 days)   0.214
Mean Duration of therapy2 19.8 days (17.9–21.8 days) 16.5 days (15–18.1 days)   0.0094
  1. 1Odds ratios are from random effects regression models that controlled for the number of hospitalizations. The reported odds ratios are the odds of having the individual variables in the AZ period relative to the AMB period
  2. 2Reported means are least squared means from mixed effects regression models that controlled for the number of hospitalizations
  3. 3age range is the observed age range of the patients in each period
  4. 4p-values are from mixed effects logistic regression models that controlled for the number of hospitalization
  5. 5p-values are from random effects logistic regression models that controlled for the number of hospitalization
  6. Note: AMB = amphotericin; AZ = Azole; FLU = fluconazole; VOR = voriconazole; NHL = non-Hodgkin's lymphoma; OR = odds ratio; Allo-transplant = allogeneic stem cell transplant; auto-transplant = autologous stem cell transplant