Rolling behavior of
infected mice. (A). Still frames of a C57BL/6 mouse infected with Salmonella enterica serovar Typhimurium (plus Additional file 1) which shows rolling behavior as a prominent feature of intracranial infection. Rotation speeds of 1 rotation per 0.3 seconds to 1.5 seconds were observed. Rotary motion was observed in either direction, though only unidirectional motion was observed for any given mouse. (B). Bacterial load in the brains of rolling and non-rolling C57BL/6 mice. Infected mice were sacrificed and the brain removed as described in the text. Brain homogenates were plated on solid LB microbiological agar for enumeration of bacterial colony forming units (cfu). Each data point represents one animal. Shown is the data scatter of log-transformed cfu per organ from each animal, with the horizontal line representing the geometric mean (P = 0.0002, Mann Whitney).