Table 1 Clinical and laboratory features of 21 children with malignancies with infectious diseases consultations prior to diagnosis
From: Pediatric malignancies presenting as a possible infectious disease
Patient | Age (yrs) Sex (M/F) | Main features at time of ID consult | DOS | Fever (days) | Bone pain (days) | Fatigue (days) | Weight loss (kg) | Headache | HMG (cm below CM) | SMG (cm below CM) | LN | Hb | WBC | Diff | Plt | LDH | Malignancy/Diagnostic Test |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1.6 F | swollen elbow, pancytopenia | high | Y(28) | No | No | No | No | Y (4) | Y (NR) | No | 63 | N | A | 6 | 1015 | ALL/BMA |
2 | 12.2 M | hip and calf pain, poor appetite, fever, bruising | high | Y(7) | No | Y (21) | Y (5) | Y | No | No | No | 52 | 14.9 | A | 19 | 869 | AML/BMA |
3 | 0.25 F | respiratory distress, shock, leukocytosis | low | No | No | No | No | No | Y (6) | Y (1) | No | N | 53 | A | 30 | 3204 | JMML/skin biopsy |
4 | 14.5 F | cough, cavitary lesions on CXR | low | Y(NR) | No | No | Y (5) | No | No | Y (1) | Y | 108 | 22.3 | N | H(615) | N | Hodgkin's/lung and mediastinal node biopsies |
5 | 1.5 F | back pain with abnormal MRI | high | Y | No | No | No | No | No | Y (1) | No | 108 | N | N | N | N | Langerhan's cell histiocytosis/vertebral aspirate |
6 | 4.7 M | fever, vomiting, abdominal pain, inguinal lymphadenopathy | low | Y(5) | No | No | No | No | No | Y (CT) | Y | 107 | N | N | N | N | Lymphoma/node biopsy |
7 | 2.3 M | splenomegaly, lymphadenopathy, abnormal CBC | high | No | No | No | No | No | No | Y (3) | Y | 77 | 30.3 | A | 67 | N | JMML/BMA |
8 | 8.6 M | parietal swelling with imaging showing possible abscess | none | No | No | Y (70) | No | No | No | No | No | 113 | 12.6 | N | H(413) | NR | fibrous histiocytoma/dural biopsy |
9 | 1.6 M | leukocytosis on CBC done for irritability and asthma | high | No | No | No | No | No | Y (U/S) | Y (U/S) | No | 84 | 51.3 | A | 106 | 438 | JCML/BMA |
10 | 3.3 F | fever, lower GI bleed, pancytopenia | high | Y (7) | No | No | No | No | No | No | No | 20 | 1.2 | A | 7 | 313 | ALL/BMA |
11 | 9.9 M | headache, blurred double vision with brain lesion on imaging | low | No | No | No | Y(5) | Y | No | No | No | N | N | N | N | N | Ependymoma/brain biopsy |
12 | 2.2 F | fever, limp, abnormal imaging | low | Y(2) | No | No | No | No | No | No | No | 106 | 4.4 | N | N | 592 | Neuroblastoma/BMA |
13 | 15. M | fever, cough, dyspnea with known pericardial and pleural effusions | low | Y(2) | No | No | No | No | No | No | No | 125 | 58.8 | A | N | N | CML/BMA |
14 | 7.2 M | parapharyngeal mass | none | No | No | No | No | No | No | No | No | N | N | N | N | N | Rhabdomyosarcoma/biopsy of parapharyngeal mass |
15 | 12.9 F | swollen elbow | low | Y(150) | Y(30) | No | No | No | No | Y(NR) | No | 90 | 1.5 | N | N | N | ALL/BMA |
16 | 5. M | fever, neutropenia | high | Y(11) | No | Y(11) | Y | Y | No | Y(tip) | No | 60 | 1.6 | A | 35 | 733 | ALL/BMA |
17 | 11.8 M | inability to weight-bear, abdominal pain | high | Y | Y(120) | Y(120) | Y | No | Y(10) | Y(1) | No | 117 | 3.5 | A | 115 | 880 | ALL/BMA |
18 | 14.6 M | fever, myalgia, back and leg pain | low | Y(40) | Y(60) | Y(60) | Y(10) | Y | No | No | No | 103 | N | N | N | 657 | Lymphoma/BMA |
19 | 14.8 F | fever, cellulitic rash, pancytopenia | high | Y(2) | Y | Y(NR) | No | No | Y (1.5) | No | No | 87 | 0.8 | A | 18 | N | ALL/BMA |
20 | 2.8 M | limp, back pain, refusal to run | none | Y(2) | Y(7) | No | No | Y | Y(U/S) | Y(U/S) | No | 71 | 4.5 | A | 83 | 484 | ALL/BMA |
21 | 11.8 M | back pain, fever | low | Y(5) | Y(2) | No | Y(5) | Y | No | No | No | 67 | N | N | N | 378 | ALL/BMA |