Table 3 Frequency of occurrence of daptomycin MIC values for key Gram-positive pathogens.
| Â | No. (%) of isolates inhibited at daptomycin MIC (mg/L) of: | ||||||
|---|---|---|---|---|---|---|---|
Organism (no. tested) | ≤0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 |
S. aureus (2,746) | 3 (0.1) | 90 (3.3) | 1.798 (65.5) | 835 (30.4) | 20 (0.7) | - | - |
   Oxacillin-susceptible (1,946) | 2 (0.1) | 75 (3.9) | 1,376 (70.7) | 485 (24.9) | 8 (0.4) | - | - |
   Oxacillin-resistant (800) | 1 (0.1) | 15 (1.9) | 422 (52.8) | 350 (43.8) | 12 (1.5) | - | - |
Coagulase-negative staphylococci (941) | 13 (1.4) | 72 (7.7) | 447 (47.5) | 381 (40.5) | 27 (2.9) | - | 1 (0.1)a |
   Oxacillin-susceptible (268) | 6 (2.2) | 30 (11.2) | 129 (48.1) | 90 (33.6) | 12 (4.5) | - | 1 (0.4)a |
   Oxacillin-resistant (673) | 7 (1.0) | 42 (6.2) | 318 (47.3) | 291 (43.2) | 15(2.2) | - | - |
E. faecalis (646) | 2 (0.3) | 2 (0.3) | 34 (5.3) | 303 (46.9) | 291 (45.0) | 14 (2.2) | - |
   Vancomycin-susceptible (640) | 2 (0.3) | 2 (0.3) | 34 (5.3) | 299 (46.7) | 289 (45.2) | 14 (2.2) | - |
   Vancomycin-non-susceptible (6) | - | - | - | 4 (66.7) | 2 (33.3) | - | - |
E. faecium (307) | - | 1 (0.3) | 3 (1.0) | 19 (6.2) | 72 (23.5) | 151 (49.2) | 61 (19.9) |
   Vancomycin-susceptible (252) | - | 1 (0.4) | 3 (1.2) | 18 (7.1) | 60 (23.8) | 120 (47.6) | 50 (19.8) |
   Vancomycin-non-susceptible (55) | - | - | - | 1 (1.8) | 12 (21.8) | 31 (56.4) | 11 (20.0) |