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Table 3 Relation between markers SLC6a/b and tuberculosis in Chinese stratified by sex and agea

From: Sex- and age-dependent association of SLC11A1polymorphisms with tuberculosis in Chinese: a case control study

Alleles/genotypes TB patients Control subjects Odds ratio (95% CI) Pvalue
Comparison of allele frequencies
   Stratification by sex and age       
Male & age ≤65       
G-TGTG 151 (89%) 163 (95%) 1  
A- ---- 19 (11%) 9 (5%) 2.28 (1.00 – 5.13) 0.0450b
Female & age ≤65       
G-TGTG 47 (78%) 55 (92%) 1  
A- ---- 13 (22%) 5 (8%) 3.04 (1.01 – 9.16) 0.0408b
Male & age >65       
G-TGTG 201 (82%) 203 (83%) 1  
A- ---- 43 (18%) 43 (17%) 1.01 (0.63 – 1.61) 0.9668
Female & age >65       
G-TGTG 63 (77%) 76 (88%) 1  
A- ---- 19 (23%) 10 (12%) 2.29 (0.99 – 5.29) 0.0478b
Comparison of genotype frequencies c
   Stratification by sex and age       
Male & age ≤65       
G-TGTG/G-TGTG 67 (79%) 79 (92%) 1  
A- ----/- 18 (21%) 7 (8%) 3.03 (1.19 – 7.70) 0.0158b
Female & age ≤65       
G-TGTG/G-TGTG 19 (63%) 25 (83%) 1  
A- ----/- 11 (37%) 5 (17%) 2.90 (0.86 – 9.75) 0.0798
Male & age >65       
G-TGTG/G-TGTG 82 (67%) 82 (67%) 1  
A- ----/- 40 (33%) 41 (33%) 0.98 (0.57 – 1.66) 0.9276
Female & age >65       
G-TGTG/G-TGTG 24 (59%) 34 (67%) 1  
A- ----/- 17 (41%) 17 (33%) 2.68 (1.02 – 7.00) 0.0419b
  1. a Markers SLC6a and SLC6b are in perfect LD and thus are analyzed as a single marker (SLC6a/b).
  2. b Not significant after correction of multiple testing based on false discovery rate at a level of 0.05. For details, see additional file 1.
  3. c The genotype A- ----/- stands for either A- ----/G-TGTG or A- ----/A- ----.