Table 1 History, clinical characteristics and drug susceptibility test results in children with culture-confirmed TB according to HIV status (n = 596)
From: Culture-confirmed childhood tuberculosis in Cape Town, South Africa: a review of 596 cases
Characteristic | HIV-uninfected N = 281 (%) | HIV-infected N = 133 (%) | HIV unknown N = 182 (%) | Odds ratio (95% CI)a |
|---|---|---|---|---|
Previous TB treatment | 26 (9.3) | 40 (30.1) | 16 (8.8) | 0.24 (0.13–0.42) |
Known TB source case | 152 (54.1) | 73 (54.9) | 70 (38.5) | NS |
Nutritional status | (n = 276) | (n = 128) | (n = 173)b | |
Severely malnourished | 53 (19.2) | 26 (20.3) | 20 (11.6) | NS |
< 3rd percentile WFA | 78 (27.8) | 57 (42.9) | 44 (24.2) | 0.49 (0.31–0.78) |
Total malnourished | 131 (46.6) | 83 (62.4) | 64 (35.2) | 0.49 (0.31–0.77) |
TST (Mantoux) positive | 190/232 (81.9) | 50/83c (60.2) | 90/110 (81.8) | 2.99 (1.66–5.38) |
DST results | (n = 277)d | |||
All drug resistance | 31 (11.2) | 23 (17.3) | 13 (7.1) | NS |
INH monoresistance | 21 (7.5) | 12 (9.0) | 10 (5.5) | NS |
RMP monoresistance | 0 | 2 (1.5) | 0 | |
MDR | 10 (3.6) | 9 (6.8) | 3 (1.6) | NS |
TB manifestation: | ||||
Intrathoracic TB onlye | 126 (44.8) | 84 (63.2) | 96 (52.7) | 0.47 (0.30–0.74) |
Intra- and extrathoracic TBe | 119 (42.3) | 44 (33.1) | 48 (26.4) | NS |
Extrathoracic TB only | 37 (13.2) | 5 (3.8) | 37 (20.3) | 3.07 (1.41–11.48) |
All extrathoracic TB | 156 (55.5) | 49 (36.8) | 85 (46.7) | 2.12 (1.36–3.32) |