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Table 3 Sensitivity, specificity, positive and negative predictive values of plasma CMV quantitative PCR

From: CMV quantitative PCR in the diagnosis of CMV disease in patients with HIV-infection – a retrospective autopsy based study

Results of CMV PCR assay

Sensitivity (%) (95% CI)

Specificity (%) (95% CI)

PPV (%) (95% CI)

NPV (%) (95% CI)

Viral load (CMV DNA copies/mL (last samples)

    

Viraemiaa

47 (34–60)

89 (80–94)

76 (59–87)

70 (60–78)

   ≥2 000

30 (20–44)

96 (89–99)

84 (62–95

65 (56–74)

   ≥10 000

17 (9–29)

100 (95–100)

100 (70–100)

62 (53–70)

CMV DNA detectiona by no. of tested samples before diagnosis

    

   One sample

    

CMV DNA detected

46 (30–65)

90 (69–97)

85 (58–96)

57 (39–73)

   Two samples

    

CMV DNA detected in at least one sample

55 (38–72)

86 (74–92)

67 (47–82)

78 (66–87)

CMV DNA detected in both samples

24 (12–42)

100 (94–100)

100 (65–100)

70 (61–80)

  1. aAny viraemia above limit of detection.
  2. Sensitivity, specificity, positive and negative predictive value of plasma CMV quantitative PCR in the diagnosis of CMV disease in HIV patients by different viral load cut-offs and number of tested samples.
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BMC Infectious Diseases

ISSN: 1471-2334

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