Table 1 Bacterial concentration and calorimetric detection time of 1 μl and 10 μl CSF punctured 18 h after intracisternal injection of bacteria (infected cases) or sterile fluid (controls). Calorimetric detection time is defined by the time from insertion of the ampoule into the calorimeter until the heat flow exceeded 10 μW. Data represent mean values ± SD.
From: Rapid diagnosis of experimental meningitis by bacterial heat production in cerebrospinal fluid
Intracisternal injection (No. of animals) | Bacterial titer in CSF (cfu/ml) | Calorimetric detection time (h)a | Peak heat flow (μW)b | |
|---|---|---|---|---|
10 μl CSF | 1 μl CSF | |||
S. pneumoniae (n = 4) | 1.5 ± 0.6 × 108 | 1.5 ± 0.2 | 2.8 ± 0.3 | 342 ± 29 |
N. meningitidis (n = 4) | 1.3 ± 0.3 × 106 | 3.9 ± 0.7 | 5.5 ± 1.1 | 75 ± 24 |
L. monocytogenes (n = 4) | 3.5 ± 2.2 × 104 | 9.1 ± 0.5 | 13.0 ± 1.0 | 340 ± 15 |
Heat-inactivated S. pneumoniae (n = 2) | No growth | Negative | Negative | <10 |
Saline control (n = 2) | No growth | Negative | Negative | <10 |