Table 2 Interaction as determined by means of checkerboard assay
Combination | Nr of MRSA strains (%) for which combinations gave | ||
|---|---|---|---|
Synergy | No interaction | Antagonism | |
LVX + VA (n = 50) | 16 (32) | 34 (68) | 0 |
LVX + TEC (n = 50) | 9 (18) | 41 (82) | 0 |
CTX + VA (n = 50) | 23 (46) | 27 (54) | 0 |
CTX + TEC (n = 50) | 43 (86) | 7 (14) | 0 |
LVX + VA + AMK (n = 25) | 5 (20) | 20 (80) | 0 |
LVX + TEC + AMK (n = 25) | 10 (40) | 15 (60) | 0 |
LVX + VA + CAZ (n = 25) | 15 (60) | 10 (40) | 0 |
LVX + TEC + CAZ (n = 25) | 20 (80) | 5 (20) | 0 |
LVX + VA + FEP (n = 25) | 10 (40) | 15 (60) | 0 |
LVX + TEC + FEP (n = 25) | 10 (40) | 15 (60) | 0 |
LVX + VA + IPM (n = 25) | 5 (20) | 20 (80) | 0 |
LVX + TEC + IPM (n = 25) | 10 (40) | 15 (60) | 0 |
LVX + VA + TZP (n = 25) | 5 (20) | 20 (80) | 0 |
LVX + TEC + TZP (n = 25) | 20 (80) | 5 (20) | 0 |