Skip to main content

Table 1

From: Vaginal microbicides: detecting toxicities in vivothat paradoxically increase pathogen transmission

agent or PBS agent then 0.1 ID50 PBS then 0.1 ID50 PBS then 10 ID50 Relative Suscept. P
12 hours earlier infected inoculated infected inoculated infected inoculated   
2% N9 29 42 8 40 35 40 29 <0.001
2% C16B 20 30 4 30 25 29 29.1 <0.001
2% C14AO 25 41 4 39 34 37 17.5 <0.001
2% BZK 28 40 9 41 37 41 25.5 <0.001
2% SDS 25 37 4 36 34 37 25.0 <0.001
2% CHX 15 45 3 45 35 44 5.4 <0.003
BufferGel 14 52 6 46 39 51 2.7 0.13
2% SPS 5 39 3 34 31 35 1.3 0.7
HEC Placebo 3 32 6 30 30 30 0.5 0.3
2% N9 at time earlier         
5 minutes 8 32 5 32 18 18 1.7 0.5
15 minutes 12 28 4 27 26 28 5.2 0.037
3 hours 26 39 14 41 23 27 12 0.007
6 hours 15 45 10 43 31 39 2.3 0.35
9 hours 22 38 3 37 35 39 16.6 <0.001
18 hours 9 37 5 34 31 36 2.2 0.4
24 hours 8 29 4 29 24 28 2.4 0.3
  2% N9 then 10 ID50
30 seconds 10 18    17 20 0.16 0.07