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Table 1

From: Vaginal microbicides: detecting toxicities in vivothat paradoxically increase pathogen transmission

agent or PBS

agent then 0.1 ID50

PBS then 0.1 ID50

PBS then 10 ID50

Relative Suscept.

P

12 hours earlier

infected

inoculated

infected

inoculated

infected

inoculated

  

2% N9

29

42

8

40

35

40

29

<0.001

2% C16B

20

30

4

30

25

29

29.1

<0.001

2% C14AO

25

41

4

39

34

37

17.5

<0.001

2% BZK

28

40

9

41

37

41

25.5

<0.001

2% SDS

25

37

4

36

34

37

25.0

<0.001

2% CHX

15

45

3

45

35

44

5.4

<0.003

BufferGel

14

52

6

46

39

51

2.7

0.13

2% SPS

5

39

3

34

31

35

1.3

0.7

HEC Placebo

3

32

6

30

30

30

0.5

0.3

2% N9 at time earlier

        

5 minutes

8

32

5

32

18

18

1.7

0.5

15 minutes

12

28

4

27

26

28

5.2

0.037

3 hours

26

39

14

41

23

27

12

0.007

6 hours

15

45

10

43

31

39

2.3

0.35

9 hours

22

38

3

37

35

39

16.6

<0.001

18 hours

9

37

5

34

31

36

2.2

0.4

24 hours

8

29

4

29

24

28

2.4

0.3

 

2% N9 then 10 ID50

30 seconds

10

18

  

17

20

0.16

0.07