From: Vaginal microbicides: detecting toxicities in vivothat paradoxically increase pathogen transmission
agent or PBS | agent then 0.1 ID50 | PBS then 0.1 ID50 | PBS then 10 ID50 | Relative Suscept. | P | |||
---|---|---|---|---|---|---|---|---|
12 hours earlier | infected | inoculated | infected | inoculated | infected | inoculated | Â | Â |
2% N9 | 29 | 42 | 8 | 40 | 35 | 40 | 29 | <0.001 |
2% C16B | 20 | 30 | 4 | 30 | 25 | 29 | 29.1 | <0.001 |
2% C14AO | 25 | 41 | 4 | 39 | 34 | 37 | 17.5 | <0.001 |
2% BZK | 28 | 40 | 9 | 41 | 37 | 41 | 25.5 | <0.001 |
2% SDS | 25 | 37 | 4 | 36 | 34 | 37 | 25.0 | <0.001 |
2% CHX | 15 | 45 | 3 | 45 | 35 | 44 | 5.4 | <0.003 |
BufferGel | 14 | 52 | 6 | 46 | 39 | 51 | 2.7 | 0.13 |
2% SPS | 5 | 39 | 3 | 34 | 31 | 35 | 1.3 | 0.7 |
HEC Placebo | 3 | 32 | 6 | 30 | 30 | 30 | 0.5 | 0.3 |
2% N9 at time earlier | Â | Â | Â | Â | Â | Â | Â | Â |
5 minutes | 8 | 32 | 5 | 32 | 18 | 18 | 1.7 | 0.5 |
15 minutes | 12 | 28 | 4 | 27 | 26 | 28 | 5.2 | 0.037 |
3 hours | 26 | 39 | 14 | 41 | 23 | 27 | 12 | 0.007 |
6 hours | 15 | 45 | 10 | 43 | 31 | 39 | 2.3 | 0.35 |
9 hours | 22 | 38 | 3 | 37 | 35 | 39 | 16.6 | <0.001 |
18 hours | 9 | 37 | 5 | 34 | 31 | 36 | 2.2 | 0.4 |
24 hours | 8 | 29 | 4 | 29 | 24 | 28 | 2.4 | 0.3 |
 | 2% N9 then 10 ID50 | |||||||
30 seconds | 10 | 18 | Â | Â | 17 | 20 | 0.16 | 0.07 |