Table 2 Allele frequencies and genotype frequencies in SARS patients and controls*
From: The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
SNP | SARS (n = 476) | Control (n = 449) | OR (95% CI) | P |
|---|---|---|---|---|
Number (%) | ||||
Genotype | ||||
IFN-γ +874 | <0.001 | |||
A/A | 332 (69.8) | 203 (45.2) | 5.19 (2.78 – 9.68) | |
A/T | 127 (26.7) | 189 (42.1) | 2.57 (1.35 – 4.88) | |
T/T | 17 (3.6) | 57 (12.7) | Reference | |
IL-10 -1082 | NS | |||
A/A | 439 (92.2) | 411 (91.5) | .. | |
A/G | 35 (7.4) | 38 (8.5) | .. | |
G/G | 2 (0.4) | 0 (0) | .. | |
IL-10 -592 | NS | |||
A/A | 244 (51.3) | 209 (46.6) | .. | |
A/C | 188 (39.5) | 214 (47.7) | .. | |
C/C | 44 (9.2) | 26 (5.8) | .. | |
TNF-a -308 | NS | |||
GG | 403 (84.7) | 377 (83.9) | .. | |
GA | 70 (14.7) | 70 (15.6) | .. | |
AA | 3 (0.6) | 2 (0.5) | .. | |
Allele | ||||
IFN-γ +874 | <0.001 | |||
A | 791 (83.1) | 595 (66.3) | 2.23 (1.75 – 2.83) | |
T | 161 (16.9) | 303 (33.7) | ||
IL-10 -1082 | NS | |||
A | 913 (95.9) | 860 (95.8) | .. | |
G | 39 (4.1) | 38 (4.2) | .. | |
IL-10 -592 | NS | |||
A | 676 (71.0) | 632 (70.4) | .. | |
C | 276 (29.0) | 266 (29.6) | .. | |
TNF-a -308 | NS | |||
G | 876 (92.0) | 824 (91.8) | .. | |
A | 76 (8.0) | 74 (8.2) | .. | |