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Table 2 Allele frequencies and genotype frequencies in SARS patients and controls*

From: The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

SNP SARS (n = 476) Control (n = 449) OR (95% CI) P
  Number (%)   
Genotype     
IFN-γ +874     <0.001
A/A 332 (69.8) 203 (45.2) 5.19 (2.78 – 9.68)  
A/T 127 (26.7) 189 (42.1) 2.57 (1.35 – 4.88)  
T/T 17 (3.6) 57 (12.7) Reference  
IL-10 -1082     NS
A/A 439 (92.2) 411 (91.5) ..  
A/G 35 (7.4) 38 (8.5) ..  
G/G 2 (0.4) 0 (0) ..  
IL-10 -592     NS
A/A 244 (51.3) 209 (46.6) ..  
A/C 188 (39.5) 214 (47.7) ..  
C/C 44 (9.2) 26 (5.8) ..  
TNF-a -308     NS
GG 403 (84.7) 377 (83.9) ..  
GA 70 (14.7) 70 (15.6) ..  
AA 3 (0.6) 2 (0.5) ..  
Allele     
IFN-γ +874     <0.001
A 791 (83.1) 595 (66.3) 2.23 (1.75 – 2.83)  
T 161 (16.9) 303 (33.7)   
IL-10 -1082     NS
A 913 (95.9) 860 (95.8) ..  
G 39 (4.1) 38 (4.2) ..  
IL-10 -592     NS
A 676 (71.0) 632 (70.4) ..  
C 276 (29.0) 266 (29.6) ..  
TNF-a -308     NS
G 876 (92.0) 824 (91.8) ..  
A 76 (8.0) 74 (8.2) ..  
  1. NS = not significant.
  2. *P-value and OR (95% CI) were calculated with the use of logistic regression models, adjusted with sex and age.