Figure 3
Pharmacokinetic levels of daptomycin in rat plasma on day 4 of therapy with twice-daily (closed symbols) or once-daily (open symbols) doses of daptomycin (30 mg/kg). The plasma AUC0-24h of rats treated with the twice-daily and once-daily regimens were 1667 and 558 mg × h/L, respectively. The values for each time point are the mean (+ SEM) daptomycin plasma levels determined in four different animals.