From: Clinical features and outcome of sporadic serogroup W135 disease Taiwan
Feature | W135 (n = 21) | Non-W135 (n = 67) | Total (n = 88) | P |
---|---|---|---|---|
No underlying disease | 16(76.2) | 53(79.1) | 69(78.4) | 0.768 |
Underlying disease of cancer | 2(9.5) | 4(6.0) | 6(6.8) | 0.626 |
Steroid use | 2(9.5) | 2(3.0) | 4(4.5) | 0.240 |
Disease classification | ||||
Meningitis | 10(47.6) | 40(59.7) | 50(56.8) | 0.329 |
Bacteremia without meningitis | 11(52.4) | 27(40.3) | 38(43.2) | 0.329 |
Bacteremia without sepsis | 2(9.5) | 5(7.5) | 7(8.0) | 0.670 |
With pneumonia | 5(23.8) | 1(1.5) | 6(6.8) | 0.003 |
With arthritis | 1(4.8) | 2(3.0) | 3(3.4) | 0.563 |
Presentation | ||||
Presentation ≤1 day after symptom onset | 12 (57.1) | 45 (67.2) | 57 (64.8) | 0.402 |
Presentation days (mean ± SD) | 1.9 ± 2.4 | 1.7 ± 3.0 | 1.8 ± 2.9 | 0.810 |
Fever | 17(81.0) | 58(86.6) | 75(85.2) | 0.501 |
Sore throat | 6(28.6) | 16(23.9) | 22(25.0) | 0.665 |
Cough | 12(57.1) | 29(43.3) | 41(46.6) | 0.267 |
Myalgia and/or arthragia | 5(23.8) | 18(26.9) | 23(26.1) | 0.781 |
Nausea and/or vomiting | 8(38.1) | 35(52.2) | 43(48.9) | 0.258 |
Headache | 7(33.3) | 26(38.8) | 33(37.5) | 0.651 |
Petechia and/or purpura | 6(28.6) | 26(38.8) | 32(36.4) | 0.395 |
Altered mental status | 8(38.1) | 31(46.3) | 39(44.3) | 0.511 |
Seizures | 2(9.5) | 5(7.5) | 7(8.0) | 0.670 |
Laboratory data | ||||
WBC count < 10,000/mm3 | 10(47.6) | 26(38.8) | 36(40.9) | 0.474 |
Platelet < 100,000/mm3 | 6(28.6) | 22(32.8) | 28(31.8) | 0.714 |
Cerebrospinal fluida | ||||
WBC count >1000/mm3 | 3/10(30.0) | 29/40(72.5) | 32/50(64.0) | 0.024 |
WBC count 100–1000/mm3 | 5/10(50.0) | 8/40(20.0) | 13/50(26.0) | 0.101 |
WBC count <100/mm3 | 2/10(20.0) | 3/40(7.5) | 5/50(10.0) | 0.258 |
Protein > 300 mg/dl | 4/9(44.4) | 11/36(30.6) | 15/45(33.3) | 0.454 |
Glucose < 10 mg/dl | 5/9(55.6) | 18/35(51.4) | 23/44(52.3) | 1.000 |
Days from presentation to antibiotics use (mean ± SD) | 0.7 ± 1.0 | 2.2 ± 5.0 | 1.8 ± 4.4 | 0.200 |
Outcome | ||||
Shock | 11(52.4) | 21(31.3) | 32 (36.4) | 0.080 |
Intubation | 9 (42.9) | 16(23.9) | 25(28.4) | 0.092 |
Attributable death | 4(19.0) | 15(22.4) | 19(21.6) | 1.000 |
Death within 48 hours | 2(9.5) | 13(19.4) | 15(17.0) | 0.293 |