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Table 2 Efficacy and tolerability of the different drugs used in 415 patients with Mediterranean spotted fever.

From: Mediterranean spotted fever: clinical and laboratory characteristics of 415 Sicilian children

  Chloramphenicol n = 107 Clarithromycin n = 230 Azithromycin n = 78 p
Mean time to defervescence (h) 40.62 41.94 47.13 0.093
Hospitalization mean (days) 5.4 3.4 4.1 0.018
Prolonged fever / relapse (%) 0 2 (0.9) 9 (11.5) < 0.01
Side effects requiring drug discontinuation (%) 0 16 (7) 1 (1.3) < 0.01