Table 3 Results of logistic regression models predicting overall change in blood CD4 cell count during ART. Responses are defined as either (i) the risk of immunological non-response (an increase of <50 cells/μl) or (ii) failure to attain an absolute CD4 cell count of ≥ 200 cells/μl after 48 weeks ART.
Risk of immumological non-respouse at 48 weeks | Risk of failure to attain CD4 cell count of ≥ 200 cells/μl at 48 weeks | ||||||
|---|---|---|---|---|---|---|---|
OR | (95% CI) | P value | OR | (95% CI) | P value | ||
Age (years) | <30 | 1.0 | 1.0 | ||||
30–39 | 3.15 | (1.09, 9.15) | 0.035 | 1.34 | (0.66, 2.72) | 0.41 | |
>40 | 3.88 | (1.13, 13.39) | 0.032 | 3.52 | (1.55, 7.99) | 0.003 | |
Sex | Female | 1.0 | |||||
Male | 0.42 | (0.13, 1.39) | 0.16 | 1.73 | (0.90, 3.35) | 0.10 | |
Baseline CD4 count | >150 | 1.0 | 1.0 | ||||
100–149 | 0.63 | (0.23, 1.72) | 0.37 | 2.49 | (0.89, 6.96) | 0.08 | |
50–99 | 0.18 | (0.05 0.70) | 0.013 | 5.97 | (2.29, 15.58) | <0.001 | |
<50 | 0.18 | (0.05, 0.72) | 0.016 | 12.11 | (4.43, 33.14) | <0.001 | |
WHO clinical stage | 1 & 2 | 1.0 | 1.0 | ||||
3 | 1.12 | (0.37, 3.40) | 0.84 | 1.32 | (0.54, 3.26) | 0.54 | |
4 | 2.11 | (0.63, 7.03) | 0.22 | 1.19 | (0.45, 3.17) | 0.72 | |
Baseline viral load | <5 log10 | 1.0 | 1.0 | ||||
>5 log10 | 0.21 | (0.07, 0.66) | 0.008 | 0.47 | (0.26, 0.86) | 0.014 | |
Follow-up viral load | <400 all visits | 1.0 | 1.0 | ||||
>400 any visit | 4.25 | (1.30, 13.87) | 0.017 | 3.00 | (1.14, 7.90) | 0.026 | |