Pseudomonas aeruginosa bloodstream infections: risk factors and treatment outcome related to expression of the PER-1 extended-spectrum beta-lactamase

Table 5 Clinical parameters, antimicrobial regimens and treatment outcome of patients with bloodstream infection (BSI) due to ESBL-negative P. aeruginosa (ESBL-N-Pa) isolates

Isolate	Age (yr)	Sex ^a	McCabe & Jackson ^b	Charlson weighted index	Primary source(s) of infection ^c	Severity of septicemia	Empirical treatment		Treatment administered after ID and AST ^d results			Treatment outcome ^e
							Agent (daily dose)	Adequate	Agent (daily dose)	Timing from BSI onset	Duration (days)
299/98	40	M	NF	0	LRTI, WI	Septic shock	IPM (1 g × 3)	Yes	Not changed	Day 1	12	FA
77/99	76	M	UF	4	LRTI, UTI	Sepsis	IPM (0.5 × 3)	Yes	Not changed	Day 0	14	CR
251/00	55	M	UF	6	Unknown	Sepsis	IPM (0.5 g × 2)	Yes	Not changed	Day -1	1	NA
746/00	64	M	NF	2	UTI	Sepsis	PIP (2 g × 2) CIP (0.5 g)	No	IPM (0.5 g × 2)	Day 5	7	CR
2497/01	34	M	NF	1	Unknown	Sepsis	PIP (2 g × 2)	No	CIP (0.5 g × 2)	Day 5	3	CR
2544/01	79	F	UF	3	Unknown	Sepsis	NET (0.15 g × 2)	No	IPM (0.5 g × 3)	Day 1	13	CR
A372/02	67	M	RF	7	WI	Severe sepsis	CIP (0.5 g × 2) AMK (0.5 g × 2)	No	IPM (0.5 × 2)	Day 4	9	CR
A480/02	69	F	NF	0	LRTI, WI	Sepsis	CIP (0.4 g × 2)	Yes	Not changed	Day 1	10	FA
659/02	71	M	RF	8	UTI	Sepsis	IPM (0.5 g × 2)	Yes	Not changed	Day 0	8	CR
694/02	93	M	UF	3	IVC	Sepsis	PTZ (2.25 g × 3)	Yes	PTZ (2.25 g × 3) AMK (0.5 g × 2)	Day 0 Day 6	7 2	CR
A276/03^f	76	M	NF	3	Unknown	Sepsis	None	No	IPM (1 g × 3)	Day 3	10	PR
A562/03^f	76	M	NF	3	Unknown	Sepsis	PTZ (2.25 g × 3)	Yes	Not changed	Day 0	15	CR
A173/03^f	76	M	NF	3	Unknown	Sepsis	PTZ (2.25 g × 3)	Yes	Not changed	Day -1	29	CR
A590/03	64	M	RF	6	LRTI, WI	Sepsis	IPM (1 g × 3) AMK (0.75 g)	Yes	AMK (1 g)	Day 2	8	RE
A424/04	36	M	UF	3	Unknown	Septic shock	IPM (0.5 g × 4)	No	MEM (1 g × 2)	Day 4	19	FA

Abbreviations for antimicrobial agents: NET, netilmicin; PIP, piperacillin; TZP, piperacillin plus tazobactam; CRO, ceftriaxone; FEP, cefepime; IPM, imipenem; MEM, meropenem; CIP, ciprofloxacin; AMK, amikacin; GEN, gentamicin.
^a Sex: F, female; M, male.
^b McCabe & Jackson classification: NF, nonfatal; UF, ultimately-fatal; RF, rapidly-fatal.
^c Primary source(s) of infection: LRTI, lower respiratory tract infection; WI, wound infection; UTI, urinary tract infection; IVC, intravascular catheter colonization.
^d ID, identification; AST, antimicrobial susceptibility test.
^e Treatment outcome: CR, complete response; PR, partial response; FA, failure; RE, relapse; NA, not assessable.
^f These strains caused three different BSI in the same patient.

ISSN: 1471-2334