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Table 3 Clinical parameters of investigated BSI cases (n = 24) due to ceftazidime-resistant P. aeruginosa strains: difference between PER-1-positive (PER-1-Pa) and ESBL-negative (ESBL-N-Pa) isolates.a

From: Pseudomonas aeruginosa bloodstream infections: risk factors and treatment outcome related to expression of the PER-1 extended-spectrum beta-lactamase

Clinical parameters PER-1-Pa ESBL-N-Pa P value b
No. BSI episodes 9 15c -
Severity of septicemia    
   - Sepsis 5 (55.6) 12 (80.0) NS
   - Severe sepsis 4 (44.4) 1 (6.7) 0.03
   - Septic shock 0 (0.0) 2 (13.3) NS
Empirical treatment provided 8 (88.9) 14 (93.3) NS
   - Adequate 1 (11.1) 9 (60.0) 0.02
Adequate treatment after ID / AST d results 1 (11.1) 12 (80.0) < 0.01
Predisposing factors for BSI infection    
   - Bladder catheter 9 (100) 7 (46.7) 0.01
   - Previous use of antibiotics 8 (88.9) 9 (60.0) NS
   - Intravascular catheter 9 (100) 7 (46.7) 0.01
   - Immunosuppressive therapy 5 (55.6) 5 (33.3) 0.04
   - Previous surgery 7 (77.8) 5 (33.3) NS
   - Drainages 2 (22.2) 5 (33.3) NS
   - Mechanical ventilation 6 (66.7) 3 (20.0) 0.03
   - Esophagogastroscopy 1 (11.1) 2 (13.3) NS
   - Other 4 (44.4) e 4 (26.6) f -
Overall secondary BSI 5 (55.6) 10 (66.7) NS
   - Urinary tract 2 (22.2) 3 (20.0) NS
   - Respiratory tract 3 (33.3) 4 (26.7) NS
   - IV catheter 1 (11.1) 1 (6.7) NS
   - Wounds 0 (0.0) 4 (26.7) NS
  1. a Data are expressed as no. (%) of patients.
  2. b -, not calculated; NS, not significant.
  3. c One patient was affected by three different BSI episodes.
  4. d ID, identification; AST, antimicrobial susceptibility tests.
  5. e Bronchoscopy (n = 1), dialysis (n = 1), parenteral feeding (n = 1), angiografhy (n = 1), and neutropenia (n = 1).
  6. f Bronchoscopy (n = 1), dialysis (n = 1), parenteral feeding (n = 1), nephrostomy (n = 1), and neutropenia (n = 1).