Candidaemia and cancer: patients are not all the same

Pasqualotto, Alessandro Comarú; Rosa, Daniela Dornelles; Medeiros, Lidia Rosi; Severo, Luiz Carlos

doi:10.1186/1471-2334-6-50

BMC Infectious Diseases

Table 2 Univariate analysis comparing non-neutropenic adult patients with candidaemia and solid tumours (group 1) and adult patients with candidaemia and other diagnoses than cancer (group 2).

From: Candidaemia and cancer: patients are not all the same

Variables	Group 1 (%)	Group 2 (%)	p value
Demographic factors
Age (median, years)	62.0	59.8	0.828^c
Male sex	56.5	54.0	0.791^a
Nosocomial infection	87.0	87.3	0.958^a
Diabetes mellitus	15.2	28.6	0.101^a
Chronic renal failure	6.5	20.6	0.040^a
HIV infection	0.0	7.9	0.072^b
Heart failure	2.2	11.1	0.135^b
Liver disease	2.2	9.7	0.235^b
Chronic obstructive pulmonary disease	4.3	25.4	0.003^a
Predisposing conditions
Transfusion of blood products	58.7	46.0	0.191^a
Gastrointestinal bleeding	17.4	20.6	0.672^a
Mucositis	6.5	0.0	0.072^b
Diarrhoea	21.7	33.3	0.185^a
Ileus	41.3	25.4	0.079^a
Corticosteroids	28.3	46.0	0.060^a
Previous bacteraemia	21.7	27.0	0.531^a
Previous shock requiring vasopressors	23.9	31.7	0.371^a
Previous stay in the intensive care unit	45.7	49.2	0.714^a
Invasive medical procedures
Central venous catheter	82.6	63.5	0.029^a
Implanted port	21.7	0.0	<0.001^b
Nephrostomy	6.5	1.6	0.308^b
Mechanical ventilation	41.3	46.0	0.623^a
Jejunostomy	10.9	6.3	0.489^b
Urinary catheter	69.6	57.1	0.186^a
Enteral feeding	54.3	54.0	0.969^a
Chest drainage	13.0	11.1	0.759^a
Abdominal drainage	23.9	12.7	0.127^a
Parenteral nutrition	28.3	19.0	0.258^a
Haemodialysis	6.5	15.9	0.137^a
Major surgery	50.0	39.7	0.284^a
Gastrointestinal surgery	32.6	14.3	0.023^a
Neurosurgery	0.0	3.2	0.508^b
Cardiothoracic surgery	6.5	9.5	0.731^b
At candidaemia
Shock requiring vasopressors	13.0	28.6	0.053^a
APACHE II score (median)	15.0	16.5	0.742^c
Concomitant bacteraemia	21.7	19.0	0.730^a
Antibiotic use
Duration (median, days)	11.5	12.0	0.513^c
Number of antibiotics (median)	3.0	3.0	0.337^c
Metronidazole or clindamycin	43.5	27.0	0.072^a
4^th generation cephalosporins	34.8	31.7	0.739^a
Glycopeptides	23.9	41.3	0.059^a
Carbapenems	10.0	27.0	0.038^a
Candida species
Candida albicans	60.9	49.2	0.227^a
Candida parapsilosis	17.4	22.2	0.535^a
Candida tropicalis	10.9	12.7	0.771^a
Candida isolation from sites other than blood
Catheter	17.4	7.9	0.133^a
Urinary	19.5	27.0	0.048^a
Breakthrough candidaemia	6.5	4.8	0.696^b
Antifungal treatment	71.7	71.4	0.972^a
Death during hospitalization	58.7	55.6	0.744^a
Total (n)	46	63	109

^a Chi-square test; ^b Fisher's exact test; ^c Mann-Whitney test.

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