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Table 2 Univariate analysis comparing non-neutropenic adult patients with candidaemia and solid tumours (group 1) and adult patients with candidaemia and other diagnoses than cancer (group 2).

From: Candidaemia and cancer: patients are not all the same

Variables Group 1 (%) Group 2 (%) p value
Demographic factors    
   Age (median, years) 62.0 59.8 0.828c
   Male sex 56.5 54.0 0.791a
   Nosocomial infection 87.0 87.3 0.958a
   Diabetes mellitus 15.2 28.6 0.101a
   Chronic renal failure 6.5 20.6 0.040a
   HIV infection 0.0 7.9 0.072b
   Heart failure 2.2 11.1 0.135b
   Liver disease 2.2 9.7 0.235b
   Chronic obstructive pulmonary disease 4.3 25.4 0.003a
Predisposing conditions    
   Transfusion of blood products 58.7 46.0 0.191a
   Gastrointestinal bleeding 17.4 20.6 0.672a
   Mucositis 6.5 0.0 0.072b
   Diarrhoea 21.7 33.3 0.185a
   Ileus 41.3 25.4 0.079a
   Corticosteroids 28.3 46.0 0.060a
   Previous bacteraemia 21.7 27.0 0.531a
   Previous shock requiring vasopressors 23.9 31.7 0.371a
   Previous stay in the intensive care unit 45.7 49.2 0.714a
Invasive medical procedures    
   Central venous catheter 82.6 63.5 0.029a
   Implanted port 21.7 0.0 <0.001b
   Nephrostomy 6.5 1.6 0.308b
   Mechanical ventilation 41.3 46.0 0.623a
   Jejunostomy 10.9 6.3 0.489b
   Urinary catheter 69.6 57.1 0.186a
   Enteral feeding 54.3 54.0 0.969a
   Chest drainage 13.0 11.1 0.759a
   Abdominal drainage 23.9 12.7 0.127a
   Parenteral nutrition 28.3 19.0 0.258a
   Haemodialysis 6.5 15.9 0.137a
   Major surgery 50.0 39.7 0.284a
   Gastrointestinal surgery 32.6 14.3 0.023a
   Neurosurgery 0.0 3.2 0.508b
   Cardiothoracic surgery 6.5 9.5 0.731b
At candidaemia    
   Shock requiring vasopressors 13.0 28.6 0.053a
   APACHE II score (median) 15.0 16.5 0.742c
   Concomitant bacteraemia 21.7 19.0 0.730a
Antibiotic use    
   Duration (median, days) 11.5 12.0 0.513c
   Number of antibiotics (median) 3.0 3.0 0.337c
   Metronidazole or clindamycin 43.5 27.0 0.072a
   4th generation cephalosporins 34.8 31.7 0.739a
   Glycopeptides 23.9 41.3 0.059a
   Carbapenems 10.0 27.0 0.038a
Candida species    
   Candida albicans 60.9 49.2 0.227a
   Candida parapsilosis 17.4 22.2 0.535a
   Candida tropicalis 10.9 12.7 0.771a
Candida isolation from sites other than blood    
   Catheter 17.4 7.9 0.133a
   Urinary 19.5 27.0 0.048a
Breakthrough candidaemia 6.5 4.8 0.696b
Antifungal treatment 71.7 71.4 0.972a
Death during hospitalization 58.7 55.6 0.744a
Total (n) 46 63 109
  1. a Chi-square test; b Fisher's exact test; c Mann-Whitney test.