Candidaemia and cancer: patients are not all the same

BMC Infectious Diseases

Table 1 Major demographic features, predisposing conditions, antifungal treatment and outcome for patients with candidaemia and solid tumours or haematological malignancies (univariate analysis).

Variables	Solid (%)	Haematological (%)	p value
Demographic factors
Age (median, years)	54.2	14.7	0.007^c
Male sex	51.6	68.4	0.194^a
Nosocomial infection	89.1	89.5	1.000^b
Predisposing conditions
Neutropenia	22.2	78.9	< 0.001^a
Duration of neutropenia (median, days)	5.0	17.0	0.004^c
Mucositis	9.4	11.1	1.000^b
Diarrhoea	29.7	21.1	0.460^a
Ileus	34.4	5.6	0.016^a
Corticosteroids	41.3	84.2	0.001^a
Chemotherapy	29.4	84.2	< 0.001^a
Previous stay in the intensive care unit	48.4	21.1	0.034^a
Invasive medical procedures
Central venous catheter	75.0	89.5	0.221^b
Implanted port	25.0	36.8	0.311^a
Mechanical ventilation	35.9	0.0	0.002^a
Urinary catheter	59.4	10.5	< 0.001^a
Parenteral nutrition	21.9	5.3	0.172^b
Haemodialysis	4.7	5.3	1.000^b
Radiotherapy	9.4	5.3	1.000^b
Major surgery	42.2	0.0	0.001^a
Gastrointestinal surgery	23.4	0.0	0.018^b
Antibiotic use
Duration (median, days)	13	15	0.996^c
Number of antibiotics (median)	3	3	0.474^c
Metronidazole or clindamycin	42.2	15.8	0.035^a
4^th generation cephalosporins	29.7	68.4	0.003^a
Glycopeptides	37.5	57.9	0.114^a
Carbapenems	12.5	15.8	0.708^b
Breakthrough candidaemia	7.8	15.6	0.376^b
Previous bactaeremia	28.1	47.4	0.116^a
Antifungal treatment	73.4	84.2	0.542^b
Death during hospitalization	53.1	36.8	0.213^a
Total (n)	64	19	83

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