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Table 3 Analysis of discrepancies between phenotypic data and the predictions obtained with different interpretation algorithms.a

From: DR_SEQAN: a PC/Windows-based software to evaluate drug resistance using human immunodeficiency virus type 1 genotypes

 

Interpretation algorithm

Inhibitor

DR_SEQAN

Retrogram

ANRS

HIVDB

RegaInst

Zidovudine (AZT)

2.8 (36)

0 (31)

0 (35)

0 (33)

2.8 (36)

Zalcitabine (ddC)

11.1 (99)

0 (20)

n.d.b

n.d.

1.4 (27)

Didanosine (ddI)

17.8 (118)

0 (21)

11.7 (94)

0 (30)

3.3 (30)

Lamivudine (3TC)

3.9 (51)

2.1 (48)

7.1 (56)

4.2 (48)

4.2 (48)

Stavudine (d4T)

12.1 (58)

2.9 (34)

0 (35)

0 (32)

0 (57)

Abacavir (ABC)

19.8 (81)

0 (24)

19 (84)

3.3 (30)

3.8 (26)

Nevirapine (NVP)

13.4 (67)

14.0 (50)

8.8 (68)

4.8 (63)

4.0 (50)

Delavirdine (DLV)

5.4 (93)

3.3 (61)

n.d.

3.4 (88)

3.2 (62)

Efavirenz (EFV)

11.5 (87)

12.8 (47)

10.8 (65)

1.6 (63)

6.3 (48)

Saquinavir (SQV)

8.9 (201)

8.1 (222)

30.0 (357)

6.4 (218)

14.4 (263)

Ritonavir (RTV)

4.6 (175)

5.4 (188)

6.5 (213)

4.1 (219)

7.6 (198)

Indinavir (IDV)

5.8 (190)

5.4 (185)

6.2 (211)

4.9 (205)

7.9 (228)

Nelfinavir (NFV)

5.6 (160)

6.0 (168)

13.9 (209)

2.9 (170)

13.0 (200)

Amprenavir (APV)

8.9 (223)

11.6 (216)

42.0 (483)

3.8 (208)

19.4 (304)

Lopinavir (LPV)

16.3 [0]c (43)

54.8 [28.6] (84)

61.6 [22.3] (112)

3.2 [3.2] (31)

37.5 [17.9] (56)

  1. a The reported values are percentages of isolates that are predicted to be sensitive to the inhibitor (S category in Table 1), but show a fold-increase of the IC50 for the inhibitor, which is above the cut-off values given in Table 2. Numbers in parenthesis indicate the total number of isolates predicted to be susceptible to the drug in the analyzed data set.
  2. b n.d., not determined.
  3. c The numbers shown between brackets represent the percentages obtained using a 10-fold cut-off value.
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BMC Infectious Diseases

ISSN: 1471-2334

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