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Table 2 Representative studies included for calculation of pooled frequency of fungal neutropenic enterocolitis

From: Invasive fungal infections in neutropenic enterocolitis: A systematic analysis of pathogens, incidence, treatment and mortality in adult patients

Study

Study type

Underlying diseases

No. FNE

No. NE

Additional study details

[5]

Retrospective MCS

AL and CL

0

20

Detailled cohort study describing 20 consecutive patients with NE

[27]

Retospective MCS

Mostly AL (some solid tumors).

1

29

Cohort study comparing 18 definite and 11 clinically diagnosed consecutive cases of NE. Substantial review.

[4]

Retrospective MCS

AL. Some other abdominal infections in other neutropenic pts. are described

2

13

Cohort study describing 13 consecutive cases of NE.

[23]

Prospective diagnostic study

AL

0

4

Relatively small but prospective ultrasound -based diagnostic study applying exactly defined diagnostic criteria

[63]

Retrospective MCS

AML

0

10

Cohort study describing 10 consecutive cases of NE. Relatively brief, but sufficient data

[64]

Retrospective MCS

AL

0

9

Detailled cohort study describing 9 consecutive patients with NE

[65]

Retrospective MCS

Metastatic breast cancer receiving docetaxel-based chemotherapy.

0

4

Small cohort study in taxane-exposed patients. Relatively brief, but sufficient data.

[17]

Retrospective MCS

AL

1

13

Cohort study describing 13 consecutive cases of NE.

[66]

Retrospective MCS

Cancer pts receiving taxane-based chemotherapy

0

5

Cohort study describing few consecutive patients with NE among 4600 courses of taxane-based therapy. Relatively brief, but sufficient data.

[18]

Retrospective MCS

AML

0

12

Detailled cohort study describing 12 consecutive patients with NE within an analysis of all infections in pat. receiving cheomtherapy

[29]

Retrospective MCS

AML

1

7

Cohort study describing 7 consecutive cases of NE.

[3]

Retrospective SCS reporting of consecutive patients

AL and some pts with CL.

0

20

The only surgical cohort study describing consecutive patients. Relatively brief, but sufficient data.

Total

  

5

146

 
  1. FNE, fungal neutropenic enterocolitis; ns, not specified; NE, neutropenic enterocolitis; AML, acute myeloid leukaemia; AL, acute leukaemia; CL chronic leukemias; pts, patient; MCS, medical case series; SCS, surgical case series