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Table 2 Representative studies included for calculation of pooled frequency of fungal neutropenic enterocolitis

From: Invasive fungal infections in neutropenic enterocolitis: A systematic analysis of pathogens, incidence, treatment and mortality in adult patients

Study Study type Underlying diseases No. FNE No. NE Additional study details
[5] Retrospective MCS AL and CL 0 20 Detailled cohort study describing 20 consecutive patients with NE
[27] Retospective MCS Mostly AL (some solid tumors). 1 29 Cohort study comparing 18 definite and 11 clinically diagnosed consecutive cases of NE. Substantial review.
[4] Retrospective MCS AL. Some other abdominal infections in other neutropenic pts. are described 2 13 Cohort study describing 13 consecutive cases of NE.
[23] Prospective diagnostic study AL 0 4 Relatively small but prospective ultrasound -based diagnostic study applying exactly defined diagnostic criteria
[63] Retrospective MCS AML 0 10 Cohort study describing 10 consecutive cases of NE. Relatively brief, but sufficient data
[64] Retrospective MCS AL 0 9 Detailled cohort study describing 9 consecutive patients with NE
[65] Retrospective MCS Metastatic breast cancer receiving docetaxel-based chemotherapy. 0 4 Small cohort study in taxane-exposed patients. Relatively brief, but sufficient data.
[17] Retrospective MCS AL 1 13 Cohort study describing 13 consecutive cases of NE.
[66] Retrospective MCS Cancer pts receiving taxane-based chemotherapy 0 5 Cohort study describing few consecutive patients with NE among 4600 courses of taxane-based therapy. Relatively brief, but sufficient data.
[18] Retrospective MCS AML 0 12 Detailled cohort study describing 12 consecutive patients with NE within an analysis of all infections in pat. receiving cheomtherapy
[29] Retrospective MCS AML 1 7 Cohort study describing 7 consecutive cases of NE.
[3] Retrospective SCS reporting of consecutive patients AL and some pts with CL. 0 20 The only surgical cohort study describing consecutive patients. Relatively brief, but sufficient data.
Total    5 146  
  1. FNE, fungal neutropenic enterocolitis; ns, not specified; NE, neutropenic enterocolitis; AML, acute myeloid leukaemia; AL, acute leukaemia; CL chronic leukemias; pts, patient; MCS, medical case series; SCS, surgical case series