Skip to main content

Table 1 Studies reporting patients with fungal neutropenic enterocolitis

From: Invasive fungal infections in neutropenic enterocolitis: A systematic analysis of pathogens, incidence, treatment and mortality in adult patients

Study Study type No. pts. with fungal NE Disease OP? Outcome Spec. Pathogen Additional study details
[45] CR 1 AML OP survived Histology Candida spp. + grampositive cocci CR providing sufficient details
[46] CS2C 1 ALL OP survived Blood culture+ histology Candida spp. CR providing sufficient details, 1 case of IFI among 2 cases of NE
[47] PCS 1 HMNS n.s. dead Blood culture Candida spp. Early detailled autopsy series (69 pts), 1 confirmed fungaemia, 3 questionable cases of IFI
[48] MCS 4 (or more) AML n.s. n.s. Blood culture Candida spp. Acurate retrospective study of D-Xylose malabsorption in110 AML patients. Malabsorption was associated with candidemia but no. of patients with this combination was not completely clear
[22] CR 1 AML NOP survived Blood culture Candida albicans + P.aeruginosa. CR providing sufficient details
[19] MCS 5 AL n.s. dead Histology Candida albicans 3 pts Candida glabrata 1 pt Aspergillus fumigatus 1 pt Large retrospective study. Important description of bowel wall thickening as negative prognostic factor in 88 pat. with NE. Limitation: Blood culture results are not reported.
[49] CS3C 1 HMNS OP survived Blood culture Fungus n.s. CS of 3 pat. with NE (1*fungaemia) among 18 pat. with abdominal complications. Few patient details. Pat. were not consecutive.
[50] CS2C 1 AML OP survived Blood culture Candida spp. CR providing sufficient details, 1 case of IFI among 2 cases with NE
[10] PCS 5 (or more) MNS n.s. dead Blood culture / histology Candida tropicalis 2 pts Candida albicans 1 pt Candida spp. 2 pts Interesting autopsy series describing heterogeneity in the pathologic features of NE. Microbiologic data are not clearly linked to individual patients. No. of pat with IFI was not exactly described.
[51] SCS 1 AA OP Dead Histology Candida spp. + bacteria Acurate CS of 8 pat. with NE (1*IFI). Pat. were not consecutive.
[52] CS2C 1 AA NOP Dead Histology Candida spp. CR providing sufficient details
[53] CS3C 1 HNHL OP survived Histology Candida spp. Larger CS of 3 pat. with NE (1*IFI) among 56 pat. with abdominal complications necessitating surgery. Pat. were not consecutive.
[27] MCS 1 HMNS NOP n.s. Blood culture Candida glabrata + Enterococcus spp. Cohort study comparing 18 definite and 11 clinically diagnosed consecutive cases of NE. Substantial review.
[4] MCS 2 AML ALL NOP dead Blood culture 1 /histology 1 Aspergillus fumigatus 1 pt Candida krusei Cohort study describing 13 consecutive cases of NE.
[54] CS3C 1 AML NOP Dead Histology Cryptococcus neoformans CR providing sufficient details of an uncommon course and pathogen
[17] MCS 1 ALL n.s. Dead Blood culture Candida spp. (+Aspergillus ?) Cohort study describing 13 consecutive cases of NE.
[55] CS2C 1 MM OP Dead Blood culture Candida tropicalis + Staph.aureus + E.coli CR providing sufficient details, 1 case of IFI among 2 cases of NE
[21] CR 1 AML NOP Dead Blood culture Candida krusei CR providing sufficient details
[20] MCS 5 AML OP 1pt n.s.4pts Dead 1pt n.s.4 pts Blood culture Candida spp. 4 pts Candida guillermondi+ Trichosporon beigelii 1 pt Cohort study describing 10 consecutive cases of NE.
[56] MCS 2 AL OP1 NOP1 Dead Histology Candida spp. Case series describing 10 consecutive cases of NE. Patients were consecutive, but only patients with histologic confirmation were analysed.
[29] MCS 1 AML n.s. survived Blood culture Candida albicans Cohort study describing 7 consecutive cases of NE.
[57] MCS 4 HMNS n.s. Dead Histology Candida spp. Early large autopsy series. Relatively few individual patient data provided.
[58] CR 1 NSCLC OP Dead Peritoneal lavage Candida albicans CR providing sufficient details
[59] CR 1 AML OP survived Histology Fungus n.s. + bacteria n.s. Short but sufficiently detailled case report embedded in a review emphasizing nursing actions
[2] SCS 3 MNS NOP Dead Blood culture Candida spp. CS including 18 pat. with clinically diagosed NE (3*fungaemia) among 58 pat. with abdominal complications. Few patient details. Pat. were not consecutive.
[60] PCS 2 AML NOP Dead Histology Candida spp. Early smaller (6 patients with NE) but detailled autopsy case series.
[61] RCS 2 AML OP Dead Histology + Blood culture 1pt Histology 1pt Candida spp. 1pt Candida spp.+ bacteria n.s. 1 pt Smaller (6 patients with NE) but detailled radiological case series.
[62] MCS 1 or more HMNS NOP Dead Histology Fungus n.s Cohort study describing 34 consecutive cases of NE. No. of pat with IFI was not exactly described.
[28] SCS 1 LY NOP Dead Histology Candida spp. Case series describing 22 patients with NE. Pat. were not consecutive. Relatively few individual microbiological data provided.Very good review.
Total 29   53       
  1. ns, not specified; NE, neutropenic enterocolitis; IFI, invasive fungal infection; AML, acute myeloid leukaemia; ALL, acute lymphatic leukemia; MM, multiple myeloma;
  2. AL, acute leukaemia; CL, chronic leukemias; MNS, malignancy not specified; HMNS, haematological malignancy not specified; LY, lymphoma; NCCLC, non-small cell lung cancer; pts patients; OP, operated; NOP, not operated; CR, case report; CS3C, case series with 3 cases; MCS, medical case series; PCS, pathological case series; RCS radiological case series; SCS, surgical case series