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Table 1 Significant genes with mean fold changes1 of at least ± 2.50 as given by microarray2

From: Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis

GeneBank identifier Gene symbol Gene name Biological process Fold change
NM_005532 IFI27 Interferon, alpha-inducible protein 27 Immune response +13.29
NM_005143 HP Haptoglobin Defence response +5.71
NM_006417 IFI44 Interferon-induced protein 44 Immune response +4.86
NM_024021 MS4A4A Membrane-spanning 4-domains, subfamily A, member 4 Signal transduction +4.42
NM_004994 MMP9 Matrix metalloproteinase 9 Collagen catabolism +3.93
BC035682 HBZ Hemoglobin, zeta Oxygen transport +3.78
NM_015535 DNAPTP6 DNA polymerase-transactivated protein 6   +3.57
NM_000519 HBD Hemoglobin, delta Oxygen transport +3.40
NM_005330 HBE1 Hemoglobin, epsilon 1 Oxygen transport +3.06
NM_006187 OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa Immune response +2.99
NM_000566 FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) Immune response +2.88
NM_006949 STXBP2 Syntaxin binding protein 2 Intracellular protein transport +2.86
NM_033255 EPSTI1 Epithelial stromal interaction 1 (breast)   +2.83
NM_002759 EIF2AK2 Eukaryotic translation initiation factor 2-alpha kinase 2 Immune response +2.78
NM_016633 ERAF Erythroid associated factor Hemoglobin metabolism +2.73
NM_006770 MARCO Macrophage receptor with collagenous structure Response to pathogenic bacteria +2.72
NM_001724 BPGM 2,3-bisphosphoglycerate mutase Carbohydrate metabolism +2.60
NM_000904 NQO2 NAD(P)H dehydrogenase, quinone 2 Electron transport +2.56
NM_006820 IFI44L Interferon-induced protein 44-like Immune response +2.55
NM_005101 G1P2 Interferon, alpha-inducible protein (clone IFI-15K) Immune response +2.54
NM_024572 GALNT14 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14   +2.53
NM_203339 CLU Clusterin Immune response +2.50
NM_005581 LU Lutheran blood group (Auberger b antigen included) Cell adhesion -2.55
NM_080819 GPR78 G protein-coupled receptor 78 G-protein coupled receptor protein signaling pathway -2.70
NM_000797 DRD4 Dopamine receptor D4 G-protein coupled receptor protein signaling pathway -2.89
NM_006249 PRB3 Proline-rich protein BstNI subfamily 3 G-protein coupled receptor protein signaling pathway -2.91
NM_021983 HLA-DRB4 Homo sapiens major histocompatibility complex, class II, DR beta 4 Immune response -3.31
NM_000558 HBA1 Hemoglobin alpha 1 Oxygen transport -4.61
L34088 HLA-DQA1 Major histocompatibility complex, class II, DQ alpha 1 Immune response -4.70
NM_001828 CLC Charcot-Leyden crystal protein Antimicrobial humoral response -6.08
  1. 1Gene expressions given as mean of the individual fold changes (signal intensity in a case minus signal intensity in the corresponding control). 2Gene expressions as given by microarray in whole blood of five male infants hospitalised with respiratory syncytial virus, subtype B, bronchiolitis versus five one year old male controls exposed to RSV during infancy but not hospitalised and/or treated for bronchiolitis