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Table 1 Significant genes with mean fold changes1 of at least ± 2.50 as given by microarray2

From: Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis

GeneBank identifier

Gene symbol

Gene name

Biological process

Fold change

NM_005532

IFI27

Interferon, alpha-inducible protein 27

Immune response

+13.29

NM_005143

HP

Haptoglobin

Defence response

+5.71

NM_006417

IFI44

Interferon-induced protein 44

Immune response

+4.86

NM_024021

MS4A4A

Membrane-spanning 4-domains, subfamily A, member 4

Signal transduction

+4.42

NM_004994

MMP9

Matrix metalloproteinase 9

Collagen catabolism

+3.93

BC035682

HBZ

Hemoglobin, zeta

Oxygen transport

+3.78

NM_015535

DNAPTP6

DNA polymerase-transactivated protein 6

 

+3.57

NM_000519

HBD

Hemoglobin, delta

Oxygen transport

+3.40

NM_005330

HBE1

Hemoglobin, epsilon 1

Oxygen transport

+3.06

NM_006187

OAS3

2'-5'-oligoadenylate synthetase 3, 100kDa

Immune response

+2.99

NM_000566

FCGR1A

Fc fragment of IgG, high affinity Ia, receptor (CD64)

Immune response

+2.88

NM_006949

STXBP2

Syntaxin binding protein 2

Intracellular protein transport

+2.86

NM_033255

EPSTI1

Epithelial stromal interaction 1 (breast)

 

+2.83

NM_002759

EIF2AK2

Eukaryotic translation initiation factor 2-alpha kinase 2

Immune response

+2.78

NM_016633

ERAF

Erythroid associated factor

Hemoglobin metabolism

+2.73

NM_006770

MARCO

Macrophage receptor with collagenous structure

Response to pathogenic bacteria

+2.72

NM_001724

BPGM

2,3-bisphosphoglycerate mutase

Carbohydrate metabolism

+2.60

NM_000904

NQO2

NAD(P)H dehydrogenase, quinone 2

Electron transport

+2.56

NM_006820

IFI44L

Interferon-induced protein 44-like

Immune response

+2.55

NM_005101

G1P2

Interferon, alpha-inducible protein (clone IFI-15K)

Immune response

+2.54

NM_024572

GALNT14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14

 

+2.53

NM_203339

CLU

Clusterin

Immune response

+2.50

NM_005581

LU

Lutheran blood group (Auberger b antigen included)

Cell adhesion

-2.55

NM_080819

GPR78

G protein-coupled receptor 78

G-protein coupled receptor protein signaling pathway

-2.70

NM_000797

DRD4

Dopamine receptor D4

G-protein coupled receptor protein signaling pathway

-2.89

NM_006249

PRB3

Proline-rich protein BstNI subfamily 3

G-protein coupled receptor protein signaling pathway

-2.91

NM_021983

HLA-DRB4

Homo sapiens major histocompatibility complex, class II, DR beta 4

Immune response

-3.31

NM_000558

HBA1

Hemoglobin alpha 1

Oxygen transport

-4.61

L34088

HLA-DQA1

Major histocompatibility complex, class II, DQ alpha 1

Immune response

-4.70

NM_001828

CLC

Charcot-Leyden crystal protein

Antimicrobial humoral response

-6.08

  1. 1Gene expressions given as mean of the individual fold changes (signal intensity in a case minus signal intensity in the corresponding control). 2Gene expressions as given by microarray in whole blood of five male infants hospitalised with respiratory syncytial virus, subtype B, bronchiolitis versus five one year old male controls exposed to RSV during infancy but not hospitalised and/or treated for bronchiolitis