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Table 3 Empiric Fluconazole Antifungal Therapy

From: Fluconazole for empiric antifungal therapy in cancer patients with fever and neutropenia

Variable, No. (%) All
(n = 103)
Treatment Failure
(n = 42)
No Treatment Failure
(n = 61)
LOS before fluconazole started, day    
   Mean (SD) 13.1 (7.2) 12.7 (6.9) 13.4 (7.4)
   Median (range) 12 (4–44) 11 (4–40) 12 (4–44)
On other systemic antifungal agent before fluconazole started    
   Amphotericin B 5 (4.9) 0 5 (8.2) †
Total fluconazole dosage, gm    
   Mean (SD) 1.2 (0.9) 1.0 (0.6) 1.2 (1.0)
   Median (range) 1.0 (0.1–4.4) 0.9 (0.2–2.6) 1.0 (0.1–4.4)
Maximum fluconazole dosage per day, mg    
   Mean (SD) 218 (93) 229 (99) 211 (88)
   100 – 150 mg 16 (15.5) 4 (9.5) 12 (19.7)
   200 mg 71 (68.9) 31 (73.8) 40 (65.6)
   400 – 600 mg 16 (15.5) 7 (16.7) 9 (14.8)
Duration on fluconazole, day    
   Mean (SD) 6.1 (4.8) 5.3 (3.5) 6.7 (5.4)
   Median (range) 5 (1–24) 4 (1–19) 5 (1–24)
Therapy after stopping fluconazole    
   Amphotericin B 35 (34.0) 25 (59.5) 10 (16.4) ‡
   Another azole angifungal agent 0   
Empiric fluconazole therapy    
   Continued after discharged 11 (10.7) 0 11 (18.0) ‡
   Stopped before discharged 92 (89.3) 42 (100%) 50 (82.0)
Indication for stopping fluconazole    
   Treatment failure 36 (35.0) 36 (85.7) 0 ‡
Positive fungal culture after starting fluconazole * 16 (15.5) 16 (38.1) 0 ‡
Persistent fever after starting fluconazole with negative bacterial and fungal cultures 17 (16.5) 17 (40.5) 0 ‡
ADE/toxicity due to fluconazole 1 (1.0) 1 (2.4) 0
Patient died 2 (1.9) 2 (4.8) 0
   Planned course completed 41 (39.8) 1 (2.4) ** 40 (65.6) ‡
   Care withdrawn/non-specified 15 (14.6) 5 (11.9) ** 10 (16.4)
  1. LOS, length of hospital stay; SD, standard deviation; ADE, adverse drug event; * Positive fungal culture included fungal tests on specimen from blood, bronchial alverolar lavage, sputum, stool, urine and catheter tip; ** treatment failure determined as presence of positive fungal culture or persistent fever with negative bacterial and fungal cultures after stopping empiric fluconazole therapy up to 7 days; † 0.05 ≤ P < 0.10, ‡ 0.001 ≤ P < 0.05 from Wilcoxon statistic, chi-square statistic or Fisher's exact test for comparision between non-failure and failure groups.