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Table 2 Patient Characteristics

From: Fluconazole for empiric antifungal therapy in cancer patients with fever and neutropenia

  All
(n = 103)
Treatment Failure
(n = 42)
No Treatment Failure
(n = 61)
Age, year, mean (SD) 51 (14.1) 51 (14.3) 51 (14.0)
Female, No. (%) 62 (60.2) 24 (57.1) 38 (62.3)
Nonwhite, No. (%) 5 (4.9) 4 (9.5) 1 (1.6)
Uninsured or Medicaid, No. (%) 12 (11.7) 6 (14.3) 6 (9.8)
Primary diagnosis, No. (%)    
   Hematological malignancies 79 (76.7) 38 (90.5) 41 (67.2) ‡
Acute leukemia/MDS 40 (38.8) 20 (47.6) 20 (32.8)
Chronic leukemia 7 (6.8) 3 (7.1) 4 (6.6)
Lymphoma 23 (22.3) 11 (26.2) 12 (19.7)
Myeloma 5 (4.9) 3 (7.1) 2 (3.3)
Hodgkin's disease 4 (3.9) 1 (2.4) 3 (4.9)
   Solid tumors 24 (23.3) 4 (9.5) 20 (32.8)
Underlying disease, No. (%) 11 (10.7) 5 (11.9) 6 (9.8)
   Cardiovascular disease 4 (3.9) 2 (4.8) 2 (3.3)
   Others * 7 (6.8) 3 (7.1) 4 (6.6)
DRG weight, mean (SD) 7.4 (3.7) 7.0 (3.6) 7.7 (3.7)
Charlson score, mean (SD) 3.0 (1.7) 2.6 (1.4) 3.3 (1.8) ‡
Charlson score ≤ 4, No. (%) 80 (77.7) 38 (90.5) 42 (68.9) ‡
Treatment before fluconazole started, No. (%)
   Steroid 17 (16.5) 7 (16.7) 10 (16.4)
   Chemotherapy 98 (95.2) 38 (90.5) 60 (98.4)
   Cyclosporin 6 (5.8) 3 (7.1) 3 (4.9)
History of Transplant, No. (%)
   Bone marrow transplant 56 (54.4) 23 (54.7) 33 (54.1)
Lab results before fluconazole started, No. (%)
   ANC ≤ 100/mm3 74 (71.8) 33 (78.6) 41 (67.2)
   Positive fungal cultures ** 19 (18.5) 9 (21.4) 10 (16.4)
Candida albicans 15 (14.6) 8 (19.1) 7 (11.5)
Yeast species 7 (6.8) 3 (7.1) 4 (6.6)
Duration before fluconazole started, day, mean (SD)
   Fever 7.9 (6.8) 7.5 (6.9) 8.3 (6.8)
   Neutropenia 6.5 (6.9) 6.5 (6.8) 6.4 (7.0)
Deceased, No. (%) 8 (7.8) 6 (14.3) 2 (3.3) †
  1. MDS, myelodysplastic syndrome; SD, standard deviation; DRG, diagnosis-related group; ANC, absolute neutrophil count;
  2. * Other underlying diseases included chronic pulmonary disease, connective tissue disease, ulcer disease, mild liver disease, mild to moderate diabetes;
  3. ** Positive fungal cultures were reported for tests on specimen collected from sputum, stool and urine; three patients had multiple positive cultures from different type of specimen;
  4. † 0.05 ≤ P < 0.10, ‡ 0.001 <P < 0.05 from Wilcoxon statistic, chi-square statistic or Fisher's exact test for comparision between non-failure and failure groups.