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Table 4 In vitro fungicidal activity of tea-tree oil, terpinen-4-ol, 1,8-cineole and comparatorsa

From: In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species

   MFC50 MFC90
Organism No. of isolates FLC (mg/L) ITC (mg/L) TTO (%v/v) TERP (%v/v) CIN (%v/v) FLC (mg/L) ITC (mg/L) TTO (%v/v) TERP (%v/v) CIN (%v/v)
Candida albicans b 35 > 64 > 4 0.25 0.03 2 > 64 > 4 0.25 0.06 2
Candida albicans c 14 > 64(7)c > 4(13) 0.5 0.25 4 > 64 > 4 0.5 0.5 4
  1. aFluconazole (FLC); Itraconazole (ITC);b FLC- and ITC- susceptible isolates. The MICs for the QC of C. krusei were 32 mg/L for FLC and 0.25 mg/L for and ITC, 0.25% v/v for TTO, 0.06% v/v for TERP and ≥ 4% v/v for CIN. The MFC was 0.125% for TERP. The MICs for the QC of C. parapsilosis were 2 mg/L for FLC and 0.06 mg/L for ITC, 0.125% v/v for TTO, 0.03 % v/v for TERP and 4% v/v for CIN. The MFC was 0.125 % v/v for TERP; cFLC, ITC resistant isolates or both; six isolates were cross resistant.