In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species

Table 3 In vitro anti-C.albicans activity of tea tree oil, terpinen-4-ol, 1,8-cineole and comparators^a

^aFluconazole (FLC); Itraconazole (ITC); ^bMICs are expressed in mg/L (FLC and ITC) or in % v/v (TTO, TERP, CIN); ^cFLC- and ITC- susceptible isolates. The MICs for the QC of C. krusei were 32 mg/L for FLC and 0.25 mg/L for ITC, 0.25% v/v for TTO, 0.06% v/v for TERP and ≥ 4% v/v for CIN. The MICs for the QC of C. parapsilosis were 2.0 mg/L for FLC and 0.06 mg/L for ITC, 0.125% v/v for TTO, 0.03 % v/v for TERP and 4% v/v for CIN; ^dFLC, ITC or both, resistant isolates; six isolates were cross resistant; ^eIn parenthesis, the number of strains tested.

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