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Table 3 In vitro anti-C.albicans activity of tea tree oil, terpinen-4-ol, 1,8-cineole and comparatorsa

From: In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species

MICb Drug Organism
   Candida albicans c (35)e Candida albicans d (14)e
MIC50 FLC 0.125 64.0 (7)d
  ITC 0.03 4.0 (13)
  TTO 0.125 0.25
  TERP 0.03 0.06
  CIN 2.0 4.0
MIC90 FLC 0.25 64.0
  ITC 0.03 4.0
  TTO 0.25 0.5
  TERP 0.06 0.06
  CIN 4.0 4.0
MIC range FLC 0.125–2.0 32.0–64.0
  ITC 0.0078-0.5 4.0
  TTO 0.06-0.5 0.25-0.5
  TERP 0.015-0.06 0.03-0.06
  CIN 1.0>4.0 > 4.0
  1. aFluconazole (FLC); Itraconazole (ITC); bMICs are expressed in mg/L (FLC and ITC) or in % v/v (TTO, TERP, CIN); cFLC- and ITC- susceptible isolates. The MICs for the QC of C. krusei were 32 mg/L for FLC and 0.25 mg/L for ITC, 0.25% v/v for TTO, 0.06% v/v for TERP and ≥ 4% v/v for CIN. The MICs for the QC of C. parapsilosis were 2.0 mg/L for FLC and 0.06 mg/L for ITC, 0.125% v/v for TTO, 0.03 % v/v for TERP and 4% v/v for CIN; dFLC, ITC or both, resistant isolates; six isolates were cross resistant; eIn parenthesis, the number of strains tested.