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Table 2 In vitro antifungal activity of tea-tree oil, terpinen-4-ol, 1,8-cineole and comparatorsa in reference strains

From: In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species

Organism FLC ITC TTO TERP CIN
  MIC mg/L MIC mg/L MIC %v/v MIC %v/v MFC %v/v MIC %v/v MFC %v/v
C. albicans ATCC 24433 0.25 0.06 0.25 0.06 0.125 > 4.0 > 4.0
C. albicans ATCC 76615 0.125 0.06 0.25 0.03 0.125 > 4.0 > 4.0
C. albicans ATCC 90029 0.125 0.03 0.25 0.03 0.125 4.0 4.0
C. albicans ATCC 10231 0.125 0.03 0.25 0.06 0.06 > 4.0 > 4.0
C. tropicalis ATCC750 1.0 0.125 0.06 0.03 0.125 > 4.0 > 4.0
C.parapsilosis ATCC 22019 2.0 0.06 0.125 0.03 0.125 > 4.0 > 4.0
C. krusei ATCC 6258 32.0 0.25 0.25 0.03 0.125 > 4.0 > 4.0
C. glabrata ATCC 90030 4.0 0.125 0.06 0.03 0.125 2.0 > 4.0
S. cerevisiae ATCC 9763 4.0 0.25 n.a. 0.03 0.125 4.0 > 4.0
C.neoformans ATCC 90112 2.0 0.03 0.03 0.015 0.06 2.0 > 4.0
C. neoformans ATCC 90113 4.0 0.125 n.a. 0.015 0.06 1.0 n.a.
  1. aFLC = Fluconazole; ITC = Itraconazole; n.a. = not assessed