Vaginal infection outcome by a fluconazole-susceptible strain C. albicans (SA-40) in oophorectomized, oestradiol-treated rats inoculated intravaginally with TTO 5% v/v (open squares), 2.5% v/v (open triangles), 1% v/v (open circles), terpinen-4-ol 1% v/v (filled triangles), fluconazole 100 μg (filled circles), Tween-80 0.001% v/v (control; filled squares) at 1, 24 and 48 hr after intravaginal C. albicans challenge (107 cells in 0.1 mL). Each curve represents the mean (± S.E.) of cfu of five rats. Data are from one of two independent experiments with similar results. At each time point considered, starting from day 2 to day 14, there was a statistically significant difference between the cfu of rats treated with fluconazole or TTO 5% or TTO 2.5% or terpinen-4-ol and those of the untreated animals.