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Table 2 The risk of tubal pathology (TP) in relation to the genotype of the single genes studied.

From: Do host genetic traits in the bacterial sensing system play a role in the development of Chlamydia trachomatis-associated tubal pathology in subfertile women?

  

1.1

1.2 and 2.2

  

n

Risk of TP

n

Risk of TP

TLR9 -1237 T>C

All subfertile women

155 (68%)

20%

72 (32%)

17%

 

CT+ subfertile women

26 (67%)

62%

13 (33%)

77%

 

Control group

66 (68%)

-

31 (32%)

-

TLR9 +2848 G>A

All subfertile women

45 (20%)

18%

182 (80%)

19%

 

CT+ subfertile women

6 (15%)

50%

33 (85%)

70%

 

Control group

15 (15%)

-

82 (85%)

-

TLR4 +896 A>Ga

All subfertile women

200 (88%)

19%

27 (12%)

22%

 

CT+ subfertile women

33 (85%)

64%

6 (15%)

83%

 

Control group

87 (90%)

-

10 (10%)

-

CD14 -260 C>Tb

All subfertile women

60 (26%)

17%

167 (74%)

20%

 

CT+ subfertile women

12 (31%)

67%

27 (69%)

67%

 

Control group

26 (27%)

-

71 (73%)

-

CARD15/NOD2

All subfertile women

211 (93%)

18%

16 (7%)

25%

Leu1007fsinsC

CT+ subfertile women

37 (95%)

65%

2 (5%)

100%

(SNP13)

Control group

95 (98%)

-

2 (2%)

-

  1. All subfertile women: n = 227, of whom 19% has tubal pathology (TP).
  2. CT + (C. trachomatis IgG-positive) subfertile women: n = 39, of whom 67% has TP.
  3. Control group: n = 97 ethnically-matched healthy employees of the VU University Medical Center.
  4. 1.1 = normal genotype (homozygous for the common allele); 1.2 = heterozygous SNP carrier (one common allele and one rare allele); 2.2 = homozygous SNP carrier (homozygous for the rare allele).
  5. a Adapted from Morré et al., 2003 [1].
  6. b Adapted from Ouburg et al., 2005 [2].
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BMC Infectious Diseases

ISSN: 1471-2334

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