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Table 1 Median (range) of histopathologic and immunohistologic rankings of features among patients with HME, RMSF, or controls. High ranks correspond to a greater degree for each histologic or immunohistologic feature.

From: Lymph node hemophagocytosis in rickettsial diseases: a pathogenetic role for CD8 T lymphocytes in human monocytic ehrlichiosis (HME)?

Histologic Feature n = 19

HME n = 6

RMSF n = 5

P HME vs. RMSF

Controls n = 8

P HME vs. controls

P RMSF vs. controls

Cellularity

11.5 (1–17)

4 (2–8)

.063

13.5 (7–19)

.245

.002

Phagocytic activity

15 (3.5–19)

13 (3.5–17)

.268

3.5 (3.5–12)

.015

.033

Necrosis

10.75 (2.5–18)

10.5 (2.5–13)

.396

10.5 (3–19)

.377

.584

Congestion/edema

11.5 (2–19)

8 (2–18)

.396

11.5 (2–17)

.638

.262

Bacterial load*

1.3

3.0

.003

1.5

.447

.025

Immunohistologic feature

HME [n]

Controls [n]***

P HME vs. controls

CD68 [n = 9]

7 [5] (1–10)

3.5 [4] (2–8)

.143

CD4 [n = 8**]

5 [4**] (3–9)

6 [4] (2–8)

1.000

CD8 [n = 9]

8 [5] (6–10)

2.5 [4] (1–5)

.008

CD20 [n = 7**]

6 [3**] (3–8)

3.5 [4] (1–7)

.288

  1. * means and Student's t-tests for semiquantitative measurement of bacterial load
  2. ** immunostaining for CD4 and CD20 was unsatisfactory for 1 and 2 HME patients, respectively.
  3. *** includes 1 case each of murine typhus, cat scratch disease, bronchopneumonia, and subarachnoid hemorrhage