Different profiles of immune reconstitution in children and adults with HIV-infection after highly active antiretroviral therapy

Table 1 Summary of immunological parameters of HIV patients and HIV-seronegative individuals for the cross-sectional study.

	HIV-Rec-adults	Healthy-adults	^(a) p	HIV-Rec-children	Healthy-children	^(b) p	^(c) p
*No. of subjects*	9	15		10	20
*T cells*
CD4⁺ (%)	33.7 (25.9; 42.3)	42 (29.3; 56.6)	0.035	30.5 (18.1; 39.98)	42.3 (29.5; 55.4)	0.001	0.193
CD8⁺ (%)	36.2 (25.7; 53.5)	22.7 (16.1; 32.3)	<0.001	38.6 (24.1; 63.9)	22.3 (13.6; 28.1)	<0.001	1
CD4⁺/μl	675 (563; 922)	864 (524; 1265)	0.815	837.5 (631; 1111)	1288 (588; 2804)	0.016	0.072
CD8⁺/μl	881 (632; 1765)	492 (196; 878)	<0.001	1038.5 (444; 2726)	673 (304; 1641)	0.091	0.620
*Thymic function*
TRECs/10⁵ PBMC	25 (10; 106)	247 (10; 865)	0.006	10186 (1430; 18026)	16097 (5944; 43620)	0.082	<0.001
IL-7 (pg/ml)	5.5 (2.9; 11.2)	4.3 (2.4; 7.5)	0.015	2.2 (0.8; 7.14)	0.6 (0.3; 1.8)	0.001	0.002

Values are expressed as median (minimum; maximum). TREC: TCR rearrangement excision circles. Differences were calculated by U-test of Mann-Whitney.
(a): p-values between HIV-Rec-adults and Healthy-adults.
(b): p-values between HIV-Rec-children and Healthy-children.
(c): p-values between HIV-Rec-adults and HIV-Rec-children.

ISSN: 1471-2334