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Table 3 MIC breakpoints for ceftazidime and chloramphenicol when compared to that of purified PLA2s enzymes.

From: In vitro antimicrobial activity of natural toxins and animal venoms tested against Burkholderia pseudomallei

Phospholipase A2
enzymes (PLA2s)
MIC mg/mL B. pseudomallei (strain KHW) MIC mg/mL B. pseudomallei (strain TES)
  Ctrl 0.5 0.25 0.125 0.0625 0.03125 Ctrl 0.5 0.25* 0.125a 0.0625 0.03125
Crotoxin B (CB) 0.65 0.012 (64%) 0.04 (61%) 0.33 (32%) 0.43 (32%) 0.56 (9%) 0.73 0.05 (73%) 0.06 (69%) 0.33 (40%) 0.43 (30%) 0.52 (21%)
Daboiatoxin (DbTx) 0.65 0.26 (39%) 0.09 (56%) 0.37 (28%) 0.49 (16%) 0.55 (10%) 0.68 0.03 (65%) 0.05 (63%) 0.24 (20%) 0.36 (8%) 0.43 (1%)
Bee venom PLA2 0.48 0.038 (38%) 0.056 (42%) 0.15 (33%) 0.24 (24%) 0.39 (9%) 0.44 0.03 (45%) 0.06 (38%) 0.27 (17%) 0.36 (8%) 0.41 (3%)
Mulgatoxin 0.46 0.07 (39%) 0.083 (37%) 0.21 (25%) 0.28 (18%) 0.39 (7%) 0.43 0.04 (40%) 0.07 (37%) 0.26 (18%) 0.32 (12%) 0.37 (7%)
Chloramphenicol 0.67 0.01 (68%) 0.03 (64%) 0.07 (60%) 0.42 (10%) 0.51 (1%) 0.77 0.026 (74%) 0.04 (73%) 0.07 (70%) 0.34 (41%) 0.37 (38%)
Ceftazidime 0.76 0.08 (58%) 0.05 (61%) 0.04 (62%) 0.24 (24%) 0.44 (22%) 0.89 0.01 (88%) 0.03 (86%) 0.09 (80%) 0.35 (47%) 0.49 (33%)
  1. * MIC values are given as mean of five replicates (n = 5), the bacterial inoculums per plate contained 3.2 × 108 cfu/mL forming units/well, Control (bacterial inoculums); aThe ceftazidime breaking points (MICs 0.125 mg/mL) against TES, *The PLA2 toxin breaking points (MICs 0.250 mg/mL) against both the strains of B. pseudomallei after 24 h incubation.